Environmental covariates: Effects on the power of sib-pair linkage methods

被引：0
|
作者：
Mandal, DM
Sorant, AJM
Pugh, EW
Marcus, SE
Klein, AP
Mathias, RA
O'Neill, J
Temiyakarn, LF
Wilson, AF
Bailey-Wilson, JE
机构：
[1] NHGRI, NIH, Trad Technol Ctr, Baltimore, MD 21224 USA
[2] Louisiana State Univ, Med Ctr, Dept Med, Sect Genet & Geriatr, New Orleans, LA 70112 USA
[3] Johns Hopkins Univ, Sch Med, Ctr Inherited Dis Res, Baltimore, MD USA
[4] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD USA
来源：
GENETIC EPIDEMIOLOGY | 1999年 / 17卷
关键词：
affected-sib-pair test; complex traits; sib-pair linkage test;
D O I：
暂无
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown. (C) 1999 Wiley-Liss, Inc.
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页码：S643 / S648
页数：6
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