IMPROVED SIB-PAIR LINKAGE TEST FOR DISEASE SUSCEPTIBILITY LOCI

被引：24
|
作者：
FARAWAY, JJ
机构：
[1] Department of Statistics, University of Michigan, Ann Arbor
来源：
GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 04期
关键词：
MOST POWERFUL TEST; SIB-PAIR METHOD; CHI-SQUARED GOODNESS OF FIT STATISTIC;
D O I：
10.1002/gepi.1370100403
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
An improved sib-pair test for linkage is introduced which is superior to the previously proposed tests. The test is derived from the standard chi-squared goodness of fit statistic by restricting the alternative hypothesis to the genetically possible. Critical values are given and exact power comparisons are made with the previously proposed tests. The new test is shown to be more powerful for finite samples as well as being asymptotically uniformly most powerful. (C) 1993 Wiley-Liss, Inc.
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页码：225 / 233
页数：9
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