A highly efficient microwave-assisted Suzuki coupling reaction of aryl perfluorooctylsulfonates with boronic acids

被引：79
|
作者：
Zhang, W [1 ]
Chen, CHT [1 ]
Lu, YM [1 ]
Nagashima, T [1 ]
机构：
[1] Univ Pittsburgh, Appl Res Ctr, Fluorous Technol Inc, Pittsburgh, PA 15238 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 09期
关键词：
D O I：
10.1021/ol0496428
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new strategy to improve the efficiency of Suzuki coupling reactions is introduced by combining fast microwave reaction with easy fluorous separation. Aryl perfluorooctylsulfonates derived from the corresponding phenols are coupled with aryl boronic acids to form biaryls under general microwave conditions. Both intermediates and products are purified by solid-phase extraction over FluoroFlash silica gel. Application of this tagging strategy to multistep synthesis of biaryl-substituted hydantoin is also described.
引用
收藏
页码：1473 / 1476
页数：4
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