New solid support for the synthesis of 3′-oligonucleotide conjugates through glyoxylic oxime bond formation

被引：13

作者：

Spinelli, Nicolas ^{[1
]}

Edupuganti, Om Prakash ^{[1
]}

Defrancq, Eric ^{[1
]}

Dumy, Pascal ^{[1
]}

机构：

[1] Univ Grenoble 1, Dept Chim Mol, UMR 5250, CNRS,ICMG FR2607, F-38041 Grenoble 9, France

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 02期

关键词：

D O I：

10.1021/ol062607b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel solid support 1 was synthesized to incorporate glyoxylic aldehyde functionality at the oligonucleotide 3'-terminus. 6-mer and 11-mer oligonucleotide sequences containing 3'-glyoxylic aldehyde functionality were prepared by using this support. These modified oligonucleotides were coupled to reporters containing an aminooxy group to prepare oligonucleotide 3'-conjugates through glyoxylic oxime bond formation. The hydrolytic stability of a glyoxylic oxime linkage was also investigated.

引用

页码：219 / 222

页数：4

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