Solid support synthesis of ester linked hydrophobic conjugates of oligonucleotides

被引：22
|
作者：
Guzaev, A [1 ]
Lönnberg, H [1 ]
机构：
[1] Univ Turku, Dept Chem, FIN-20140 Turku, Finland
来源：
TETRAHEDRON | 1999年 / 55卷 / 30期
基金：
芬兰科学院;
关键词：
carboxylic acids and derivatives; nucleic acid analogues; phosphoramidites;
D O I：
10.1016/S0040-4020(99)00501-3
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel non-nucleosidic phosphoramidite building block 2 was employed for multiple modification of oligonucleotides with hydrophobic octyl groups. Hydrophobic sites are attached via potentially biodegradable ester bonds that are demonstrated to withstand the conditions of DNA deprotection. The chimeric oligonucleotides are capable of forming triple helix complexes that are stabilized by forming a hydrophobic clamp consisting of terminal octyl groups. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：9101 / 9116
页数：16
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