A novel solid support for the synthesis of 3′-aminoalkylated oligonucleotides

被引：4

作者：

Leuck, M ^{[1
]}

Giare, R ^{[1
]}

Paul, M ^{[1
]}

Zien, N ^{[1
]}

Wolter, A ^{[1
]}

机构：

[1] Proligo Biochem GmbH Hamburg, D-21147 Hamburg, Germany

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 02期

关键词：

3 '-amino modified oligonucleotides; amino-ON CPG;

D O I：

10.1016/j.tetlet.2003.10.166

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel improved controlled pore glass (CPG) support based on the 2-(hydroxymethyl)-6-nitrobenzoyl (HMNB) protecting group was developed for the synthesis of 3'-aminoalkylated oligonucleotides. The release of oligonucleotides with free 3'-amino groups from the support is complete within 2 h at 55 degreesC in concentrated ammonia. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：317 / 320

页数：4

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