Palladium-Catalyzed Synthesis of Biaryl Ketones via tert-Butyl Isocyanide Insertion

被引：15

作者：

Chen, Zhong ^{[1
]}

Duan, Huaqing ^{[1
]}

Jiang, Xiao ^{[1
]}

Wang, Jinmei ^{[1
]}

Zhu, Yongming ^{[1
]}

Yang, Shilin ^{[1
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China

来源：

SYNLETT | 2014年 / 25卷 / 10期

关键词：

isocyanide; carbonylative Suzuki coupling; palladium catalyst; diaryl ketone; insertion reaction; CROSS-COUPLING REACTION; ARYLBORONIC ACIDS; DIRECT ACCESS; ARYL HALIDES; DERIVATIVES; ALDEHYDES; ACTIVATION; INHIBITORS; 4-AMINOQUINAZOLINES; BENZOPHENONES;

D O I：

10.1055/s-0033-1341244

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient palladium-catalyzed carbonylative Suzuki coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of diaryl ketones in moderate to good yields. The approach is tolerant to a wide range of substrates and applicable to library synthesis. A possible reaction mechanism was proposed based on the experimental results.

引用

页码：1425 / 1430

页数：6

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