Palladium-Catalyzed Synthesis of β,β-Diaryl α,β-Unsaturated Ketones

被引：4
|
作者：
Zheng, Yi-lin [1 ]
Xiao, Li [1 ]
Xie, Qiong [1 ]
Shao, Li-ming [1 ,2 ]
机构：
[1] Fudan Univ, Sch Pharm, Dept Med Chem, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
[2] Fudan Univ, State Key Lab Med Neurobiol, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2019年 / 51卷 / 06期
基金：
中国国家自然科学基金;
关键词：
ketones; palladium; 4,5-diazafluoren-9-one; oxidation; cross-coupling; AEROBIC DEHYDROGENATION; MOLECULAR-OXYGEN; HECK REACTIONS; OXIDATIVE REARRANGEMENT; KETENE DITHIOACETALS; CARBONYL-COMPOUNDS; ARYL HALIDES; PD; ELIMINATION; ARYLATION;
D O I：
10.1055/s-0037-1611354
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We herein describe a versatile palladium-catalyzed synthesis of ,-diaryl ,-unsaturated ketones. A broad range of aryl halides react with -arylbutanones to afford biologically useful, symmetrical and unsymmetrical ketones. The use of 4,5-diazafluoren-9-one and oxygen makes this one-pot reaction more applicable. A plausible mechanism involving palladium-catalyzed oxidative Heck-type cross-coupling is also proposed.
引用
收藏
页码：1455 / 1465
页数：11
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