Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

被引:20
|
作者
Zhou, Bowen [1 ]
Blanchard, Anne [1 ,2 ]
Wang, Nan [2 ]
Ma, Xiuli [1 ]
Han, Jihyun [1 ]
Schroedter, Ingo [1 ]
Leygue, Etienne [3 ]
Myal, Yvonne [1 ,2 ]
机构
[1] Univ Manitoba, Dept Pathol, Fac Hlth Sci, Coll Med, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Fac Hlth Sci, Dept Physiol & Pathophysiol, Coll Med, Winnipeg, MB, Canada
[3] Univ Manitoba, Fac Hlth Sci, Dept Biochem & Human Genet, Coll Med, Winnipeg, MB, Canada
关键词
Claudin; 1; Breast cancer; Tamoxifen; Migration; MCF7; Estrogen; TGF beta; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-CELLS; TIGHT JUNCTIONS; TUMOR INVASION; L EXPRESSION; APOPTOSIS; CISPLATIN; ACTIVATION; ETOPOSIDE;
D O I
10.3109/07357907.2015.1060996
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGF beta. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.
引用
收藏
页码:429 / 439
页数:11
相关论文
共 50 条
  • [21] Compensatory effects of the human nucleoside transporters on the response to nucleoside-derived drugs in breast cancer MCF7 cells
    Cano-Soldado, Pedro
    Molina-Arcas, Miriam
    Alguero, Berta
    Larrayoz, Ignacio
    Lostao, M. Pilar
    Grandas, Anna
    Casado, F. Javier
    Pastor-Anglada, Marcal
    BIOCHEMICAL PHARMACOLOGY, 2008, 75 (03) : 639 - 648
  • [22] Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells
    Dieudonne, Marie-Noelle
    Bussiere, Marianne
    Dos Santos, Esther
    Leneveu, Marie-Christine
    Giudicelli, Yves
    Pecquery, Rene
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 345 (01) : 271 - 279
  • [23] Azacytidine-induced Chemosensitivity to Doxorubicin in Human Breast Cancer MCF7 Cells
    Khan, Gul Nabi
    Kim, Eun Jin
    Shin, Tae Seop
    Lee, Sang Ho
    ANTICANCER RESEARCH, 2017, 37 (05) : 2355 - 2364
  • [24] ESTROGENIC EFFECT OF TAMOXIFEN AND ITS DERIVATIVES ON THE PROLIFERATION OF MCF7 HUMAN-BREAST TUMOR-CELLS
    SONNENSCHEIN, C
    PAPENDORP, JT
    SOTO, AM
    LIFE SCIENCES, 1985, 37 (04) : 387 - 394
  • [25] COMPARISON OF THE RADIATION SENSITIVITY OF THE BREAST CANCER CELL LINE MCF7 AND HUMAN ADIPOSE-DERIVED STEM CELLS
    Michaelidesova, Anna
    Vachelova, Jana
    Cupal, Lukas
    Konirova, Jana
    Brabcova, Katerina Pachnerova
    Bacakova, Lucie
    Vandrovcova, Marta
    Davidkova, Marie
    RADIATION PROTECTION DOSIMETRY, 2019, 186 (2-3) : 155 - 158
  • [26] Green-synthesized Zinc oxide nanoparticle, an efficient safe anticancer compound for human breast MCF7 cancer cells
    Salari, Sahar
    Neamati, Ali
    Tabrizi, Masoud Homayouni
    Seyedi, Seyed Mohammad Reza
    APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (03)
  • [27] Encapsulation of berberine into liquid crystalline nanoparticles to enhance its solubility and anticancer activity in MCF7 human breast cancer cells
    Loo, Yan Shan
    Madheswaran, Thiagarajan
    Rajendran, Ramkumar
    Bose, Rajendran J. C.
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 57
  • [28] Anticancer potential of steviol in MCF-7 human breast cancer cells
    Gupta, Ena
    Kaushik, Shweta
    Purwar, Shalini
    Sharma, Ramesh
    Balapure, Anil K.
    Sundaram, Shanthy
    PHARMACOGNOSY MAGAZINE, 2017, 13 (51) : 345 - 350
  • [29] Methyl Antcinate A Suppresses the Population of Cancer Stem-Like Cells in MCF7 Human Breast Cancer Cell Line
    Peng, Chih-Yu
    Fong, Pin-Chung
    Yu, Cheng-Chia
    Tsai, Wan-Chi
    Tzeng, Yew-Min
    Chang, Wen-Wei
    MOLECULES, 2013, 18 (03): : 2539 - 2548
  • [30] HUMAN-BREAST FIBROBLASTS ARE MITOGENIC INVIVO FOR MCF7 HUMAN-BREAST CANCER-CELLS
    HORGAN, K
    JONES, D
    MANSEL, RE
    BRITISH JOURNAL OF SURGERY, 1986, 73 (12) : 1032 - 1032