Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

被引：20

作者：

Zhou, Bowen ^{[1
]}

Blanchard, Anne ^{[1
,2
]}

Wang, Nan ^{[2
]}

Ma, Xiuli ^{[1
]}

Han, Jihyun ^{[1
]}

Schroedter, Ingo ^{[1
]}

Leygue, Etienne ^{[3
]}

Myal, Yvonne ^{[1
,2
]}

机构：

[1] Univ Manitoba, Dept Pathol, Fac Hlth Sci, Coll Med, Winnipeg, MB R3T 2N2, Canada

[2] Univ Manitoba, Fac Hlth Sci, Dept Physiol & Pathophysiol, Coll Med, Winnipeg, MB, Canada

[3] Univ Manitoba, Fac Hlth Sci, Dept Biochem & Human Genet, Coll Med, Winnipeg, MB, Canada

来源：

CANCER INVESTIGATION | 2015年 / 33卷 / 09期

关键词：

Claudin; 1; Breast cancer; Tamoxifen; Migration; MCF7; Estrogen; TGF beta; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-CELLS; TIGHT JUNCTIONS; TUMOR INVASION; L EXPRESSION; APOPTOSIS; CISPLATIN; ACTIVATION; ETOPOSIDE;

D O I：

10.3109/07357907.2015.1060996

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGF beta. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.

引用

页码：429 / 439

页数：11