Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion

被引：12
|
作者：
Kim, Eun Kyoung [1 ]
Ha, Jung Min [1 ]
Kim, Young Whan [1 ]
Jin, Seo Yeon [1 ]
Ha, Hong Koo [2 ]
Bae, Sun Sik [1 ]
机构：
[1] Pusan Natl Univ, Sch Med, Dept Pharmacol, MRC Ischem Tissue Regenerat,Med Res Inst, Pusan 609735, South Korea
[2] Pusan Natl Univ, Dept Urol, Sch Med, Pusan 609735, South Korea
来源：
FEBS LETTERS | 2014年 / 588卷 / 17期
关键词：
alpha-Linolenic acid; Lysophosphatidic acid; Migration; Adhesion; Vinculin; Calcium mobilization; SELECTIVE ACTIVATION; RHO; VINCULIN; METASTASIS; CROSSTALK; RECEPTORS; INTEGRINS; SECRETION; MOTILITY; SIGNALS;
D O I：
10.1016/j.febslet.2014.05.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group-containing PUFAs inhibit lysophosphatidic acid (LPA)-induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group-containing PUFAs inhibit LPA-induced calcium mobilization, whereas ethyl ester-group containing PUFAs have no effect. In addition, carboxyl group-containing PUFAs functionally inhibit LPA-dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA-induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group-containing PUFAs may have a functional role in this regulatory mechanism. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2971 / 2977
页数：7
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