Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion

被引：12
|
作者：
Kim, Eun Kyoung [1 ]
Ha, Jung Min [1 ]
Kim, Young Whan [1 ]
Jin, Seo Yeon [1 ]
Ha, Hong Koo [2 ]
Bae, Sun Sik [1 ]
机构：
[1] Pusan Natl Univ, Sch Med, Dept Pharmacol, MRC Ischem Tissue Regenerat,Med Res Inst, Pusan 609735, South Korea
[2] Pusan Natl Univ, Dept Urol, Sch Med, Pusan 609735, South Korea
来源：
FEBS LETTERS | 2014年 / 588卷 / 17期
关键词：
alpha-Linolenic acid; Lysophosphatidic acid; Migration; Adhesion; Vinculin; Calcium mobilization; SELECTIVE ACTIVATION; RHO; VINCULIN; METASTASIS; CROSSTALK; RECEPTORS; INTEGRINS; SECRETION; MOTILITY; SIGNALS;
D O I：
10.1016/j.febslet.2014.05.052
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group-containing PUFAs inhibit lysophosphatidic acid (LPA)-induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group-containing PUFAs inhibit LPA-induced calcium mobilization, whereas ethyl ester-group containing PUFAs have no effect. In addition, carboxyl group-containing PUFAs functionally inhibit LPA-dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA-induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group-containing PUFAs may have a functional role in this regulatory mechanism. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2971 / 2977
页数：7
相关论文
共 50 条
  • [21] Inhibitory effect of fish oil N-3 polyunsaturated fatty acids on the expression of endothelial cell adhesion molecules
    CollieDuguid, ESR
    Wahle, KWJ
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 220 (03) : 969 - 974
  • [22] Role of TAZ in Lysophosphatidic Acid-Induced Migration and Proliferation of Human Adipose-Derived Mesenchymal Stem Cells
    Mo, Won Min
    Kwon, Yang Woo
    Jang, Il Ho
    Choi, Eun Jung
    Kwon, Sang Mo
    Kim, Jae Ho
    BIOMOLECULES & THERAPEUTICS, 2017, 25 (04) : 354 - 361
  • [23] INHIBITION OF CARMA3 IMPAIRS LYSOPHOSPHATIDIC ACID-INDUCED LUNG CANCER CELL MIGRATION AND INVASION THROUGH NF-KAPPAB
    Sun, J.
    Cai, J.
    Feng, Y.
    JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (05) : S43 - S44
  • [24] Role of polyunsaturated fatty acids in the inhibitory effect of human adipocytes on osteoblastic proliferation
    Maurin, AC
    Chavassieux, PM
    Vericel, E
    Meunier, PJ
    BONE, 2002, 31 (01) : 260 - 266
  • [25] Role of Polyunsaturated Fatty Acids and Fatty Acid Binding Protein in the Pathogenesis of Schizophrenia
    Maekawa, Motoko
    Owada, Yuji
    Yoshikawa, Takeo
    CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (02) : 168 - 175
  • [26] The role of fatty acid binding proteins and polyunsaturated fatty acids in hippocampal neurogenesis
    Osumi, Noriko
    Matsumata, Miho
    Sakayori, Nobuyuki
    Maekawa, Motoko
    Yoshikawa, Takeo
    Owada, Yuji
    Kontani, Masanori
    Kawashima, Hiroshi
    Kiso, Yoshinobu
    MECHANISMS OF DEVELOPMENT, 2009, 126 : S240 - S240
  • [27] Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion
    Sengupta, S.
    Kim, K. S.
    Berk, M. P.
    Oates, R.
    Escobar, P.
    Belinson, J.
    Li, W.
    Lindner, D. J.
    Williams, B.
    Xu, Y.
    ONCOGENE, 2007, 26 (20) : 2894 - 2901
  • [28] Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion
    S Sengupta
    K S Kim
    M P Berk
    R Oates
    P Escobar
    J Belinson
    W Li
    D J Lindner
    B Williams
    Y Xu
    Oncogene, 2007, 26 : 2894 - 2901
  • [29] Role of PPARα in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes
    Emma M. Tillman
    Peihong Guan
    Timothy J. Howze
    Richard A. Helms
    Dennis D. Black
    Pediatric Research, 2016, 79 : 754 - 758
  • [30] Role of PPARα in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes
    Tillman, Emma M.
    Guan, Peihong
    Howze, Timothy J.
    Helms, Richard A.
    Black, Dennis D.
    PEDIATRIC RESEARCH, 2016, 79 (05) : 754 - 758
12345