The phosphoinositide-3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption

被引:0
|
作者
Gyori, D. [1 ]
Csete, D. [1 ]
Kulkarni, S. [2 ]
Benko, S. [3 ]
Mandl, P. [4 ]
Dobo-Nagy, C. [1 ]
Vanhaesebroeck, B. [5 ]
Stephens, L. [2 ]
Hawkins, P. T. [2 ]
Mocsai, A. [1 ]
机构
[1] Semmelweis Univ, Sch Med, Dept Physiol, Budapest, Hungary
[2] Babraham Inst, Cambridge, England
[3] Univ Debrecen, Dept Physiol, H-4012 Debrecen, Hungary
[4] Univ Vienna, Div Rheumatol, Vienna, Austria
[5] Barts Canc Ctr, Ctr Cell Signaling, London, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:40 / 40
页数:1
相关论文
共 50 条
  • [1] The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice
    Gyori, David
    Csete, Daniel
    Benko, Szilvia
    Kulkarni, Suhasini
    Mandl, Peter
    Dobo-Nagy, Csaba
    Vanhaesebroeck, Bart
    Stephens, Len
    Hawkins, Phillip T.
    Mocsai, Attila
    ARTHRITIS & RHEUMATOLOGY, 2014, 66 (08) : 2210 - 2221
  • [2] Phosphoinositide-3-kinase (PI3K) inhibitors: Identification of new scaffolds using virtual screening
    Frederick, Raphael
    Mawson, Claire
    Kendall, Jackie D.
    Chaussade, Claire
    Rewcastle, Gordon W.
    Shepherd, Peter R.
    Denny, William A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (20) : 5842 - 5847
  • [3] A novel cellular class I phosphoinositide-3-kinase (PI3K) isoform-specific occupancy assay demonstrates a direct correlation between PI3K isoform activity and phospho-AKT levels
    Gu, Lina
    Brophy, Erin
    Murphy, Erin
    Tillotson, Bonnie
    DiNitto, Jonathan
    Grenier, Louis
    Ali, Janid
    CANCER RESEARCH, 2015, 75
  • [4] The phosphoinositide 3-kinase β regulates osteoclastic bone resorption
    Gyori, D.
    Kulkarni, S.
    Benko, Sz.
    Mandl, P.
    Vanhaesebroeck, B.
    Hawkins, P.
    Mocsai, A.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2013, 43 : 34 - 34
  • [5] Dual inhibition of phosphoinositide-3-kinase (PI3K) and mTOR shows enhanced efficacy in human neuroblastomas (NBs)
    Ho, Ruth
    Minturn, Jane
    Brown, Valerie
    Iyer, Radhika
    Sheen, Cecillia
    Hulitt, Jessica
    Simpson, Anisha
    Light, Jennifer
    Varela, Carly
    Kolla, Venkatadri
    Evans, Audrey
    Brodeur, Garrett
    CANCER RESEARCH, 2009, 69
  • [6] Free-Wilson Analysis of Comprehensive Data on Phosphoinositide-3-kinase (PI3K) Inhibitors Reveals Importance of N-Methylation for PI3Kδ Activity
    Barnes, Lydia
    Blaber, Hollie
    Brooks, David T. K.
    Byers, Lewis
    Buckley, Daniel
    Byron, Zoe C.
    Chilvers, Richard G.
    Cochrane, Liam
    Cooney, Edward
    Damian, Heather A.
    Francis, Luke
    He, Daniel Fu
    Grace, Jack M. J.
    Green, Harley J.
    Hogarth, Edmund J. P.
    Jusu, Leyla
    Killalea, C. Elizabeth
    King, Oliver
    Lambert, Joseph
    Lee, Zoe J.
    Lima, Nuria S.
    Long, Christina L.
    Mackinnon, May-Li
    Mahdy, Shusha
    Matthews-Wright, Jolyon
    Millward, Makenzie J.
    Meehan, Matthew F.
    Merrett, Christopher
    Morrison, Lisa
    Parke, Hal R. I.
    Payne, Charlotte
    Payne, Lawrence
    Pike, Craig
    Seal, Alexander
    Senior, Aaron J.
    Smith, Keenan M.
    Stanelyte, Kamile
    Stillibrand, Joe
    Szpara, Rachel
    Taday, Freya F. H.
    Threadgould, Antony M.
    Trainor, Rohan J.
    Waters, Jordan
    Williams, Oliver
    Wong, Carrie K. W.
    Wood, Katherine
    Barton, Nick
    Gruszka, Anna
    Henley, Zoe
    Rowedder, James E.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (22) : 10402 - 10422
  • [7] Effects of the Cathepsin K Inhibitor Odanacatib on Osteoclast-Mediated Bone Resorption.
    Jung, J.
    Hong, J.
    Kim, T.
    Lee, S.
    Ha, M.
    Kim, H.
    Park, E.
    Kim, S.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S405 - S405
  • [8] Antibody to beta(3) integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat
    Crippes, BA
    Engleman, VW
    Settle, SL
    Delarco, J
    Ornberg, RL
    Helfrich, MH
    Horton, MA
    Nickols, GA
    ENDOCRINOLOGY, 1996, 137 (03) : 918 - 924
  • [9] Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors
    Pemberton, Nils
    Mogemark, Mickael
    Arlbrandt, Susanne
    Bold, Peter
    Cox, Rhona J.
    Gardelli, Cristina
    Holden, Neil S.
    Karabelas, Kostas
    Karlsson, Johan
    Lever, Sarah
    Li, Xueshan
    Lindrnark, Helena
    Norberg, Monica
    Perry, Matthew W. D.
    Petersen, Jens
    Blomqvist, Sandra Rodrigo
    Thomas, Matthew
    Tyrchan, Christian
    Eriksson, Annika Westin
    Zlatoidsky, Pavol
    Osterg, Linda
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (12) : 5435 - 5441
  • [10] Phosphoinositide 3-kinase δ (PI3Kδ) in respiratory disease
    Stokes, Clare A.
    Condliffe, Alison M.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2018, 46 : 361 - 369