Arylpiperazine substituted heterocycles as selective α1a adrenergic antagonists

被引：15

作者：

Khatuya, H ^{[1
]}

Hutchings, RH ^{[1
]}

Kuo, GH ^{[1
]}

Pulito, VL ^{[1
]}

Jolliffe, LK ^{[1
]}

Li, XB ^{[1
]}

Murray, WV ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Drug Discovery Res, Raritan, NJ 08869 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(02)00436-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antagonists of the alpha(1)-adrenergic receptors (alpha(1)-ARs) are useful for the treatment of benign prostatic hyperplasia. A series of potent and subtype-selective alpha(1a)-AR antagonists has been synthesized, displaying in vitro binding affinity in the low the nanomolar range. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2443 / 2446

页数：4

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