Novel heterocycles as selective α1-adrenergic receptor antagonists

被引：7
|
作者：
Li, XB
McCoy, KA
Murray, WV
Jolliffe, L
Pulito, V
机构：
[1] RW Johnson Pharmaceut Res Inst, San Diego, CA 92121 USA
[2] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(00)00472-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of aryl piperazine substituted heterocycles has been synthesized and identified as antagonists of the alpha (1a) adrenergic receptor (alpha (1a)-AR), which has been implicated in benign prostatic hyperplasia (BPH). These compounds selectively inhibit binding to the alpha (1a)-AR with K(i)s as low as 2.1 nM. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2375 / 2377
页数：3
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