Cyclic imides as potent and selective α-1A adrenergic receptor antagonists

被引：16

作者：

DiPardo, RM

Patane, MA

Newton, RC

Price, RA

Broten, TP

Chang, RSL

Ransom, RW

Di Salvo, J

Freidinger, RM

Bock, MG ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Med Chem, W Point, PA 19486 USA

[2] Merck & Co Inc, Dept Cardiovasc Pharmacol, W Point, PA 19486 USA

[3] Merck & Co Inc, Dept New Lead Pharmacol, W Point, PA 19486 USA

[4] Merck & Co Inc, Dept Biochem & Physiol, W Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(01)00320-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We disclose a new compound class of potent and selective alpha -1A adrenergic receptor antagonists exemplified by the geminally, disubstituted cyclic imide 7. The optimization of lead compounds resulting in the cyclic imide motif is highlighted. The results of in vitro and in vivo studies of selected compounds are presented. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1959 / 1962

页数：4

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