Reduced Neutrophil Elastase Activity and Neutrophil Extracellular Traps in Pediatric Acute Myeloid Leukemia May Increase the Rate of Infections

被引：11

作者：

Berger-Achituv, Sivan ^{[1
,2
]}

Elhasid, Ronit ^{[1
,2
,3
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Dept Pediat Hematooncol, Tel Aviv, Israel

[2] Tel Aviv Sourasky Med Ctr, Dana Childrens Hosp, Res Lab Pediat Hematooncol, 6 Weizmann St, IL-6423906 Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2018年 / 40卷 / 04期

关键词：

acute lymphoblastic leukemia; acute myeloid leukemia; children; hydrogen peroxide; infections; myeloperoxidase; neutrophil elastase; neutrophil extracellular traps; phagocytosis; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDHOOD; RELEASE; LEUKOCYTES; CHROMATIN; PROGRESS; DAMAGE; NETS;

D O I：

10.1097/MPH.0000000000001015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Data on the production of neutrophil extracellular traps (NETs) in leukemia patients are scant. Phagocytosis, hydrogen peroxide, neutrophil elastase and myeloperoxidase enzymatic activity as well as NETs formation were studied in 10 pediatric acute lymphoblastic leukemia and 7 pediatric acute myeloid leukemia (AML) patients after induction chemotherapy. Median neutrophil elastase activity and NETs formation were lower in AML versus acute lymphoblastic leukemia (41% vs. 90%, P=0.005 and 51% vs. 94%, P=0.008, respectively). AML patients had more episodes of febrile neutropenia during the first 2 blocks of treatment (100% vs. 40%, P=0.011) and a trend for more invasive bacterial and fungal infections.

引用

页码：E248 / E252

页数：5

共 30 条

[21] Neutrophil elastase is important for the development of acute promyelocytic leukemia (APL) in mice that express PML-RARα in early myeloid cells.
Lane, AA
Ley, TJ
BLOOD, 2003, 102 (11) : 219A - 220A
[22] Reduced DNASE1L3 Activity and Increased Anti-NET Protective Antibodies Contributes to Accumulation of Neutrophil Extracellular Traps in Pediatric SLE Patients
Barnes, Betsy
Thomas, Lydia
Battaglia, Jenna Battaglia
Simpfendorfer, Kim
Hui-Yuen, Joyce
Sharma, Vinay
Matta, Bharati
ARTHRITIS & RHEUMATOLOGY, 2023, 75 : 3403 - 3404
[23] Reduction in neutrophil extracellular traps may contribute to the effect of abatacept on clinical outcomes in pediatric patients undergoing allogeneic hematopoietic stem cell transplant
Ibrahimova, Azada
Luebbering, Nathan
Strecker, Lauren
Abdullah, Sheyar
Koo, Jane
Gloude, Nicholas
Duell, Alexandra
Lake, Kelly E.
Lane, Adam
Myers, Kasiani
Khandelwal, Pooja
Dandoy, Christopher
Jodele, Sonata
Davies, Stella M.
PEDIATRIC BLOOD & CANCER, 2022, 69
[24] DIAGNOSIS OF ACUTE MYELOID-LEUKEMIA WITH THE USE OF MONOCLONAL ANTI-NEUTROPHIL ELASTASE (NP57) REACTIVE WITH ROUTINELY PROCESSED BIOPSY SAMPLES
RALFKIAER, E
PULFORD, KAF
LAURITZEN, AF
AVNSTROM, S
GULDHAMMER, B
MASON, DY
HISTOPATHOLOGY, 1989, 14 (06) : 637 - 643
[25] Integrated multiomics analysis and machine learning refine neutrophil extracellular trap-related molecular subtypes and prognostic models for acute myeloid leukemia
Zhong, Fangmin
Yao, Fangyi
Wang, Zihao
Liu, Jing
Huang, Bo
Wang, Xiaozhong
FRONTIERS IN IMMUNOLOGY, 2025, 16
[26] Panton-Valentine leukocidin-induced neutrophil extracellular traps lack antimicrobial activity and are readily induced in patients with recurrent PVL + -Staphylococcus aureus infections
Jhelum, Hina
Cerina, Dora
Harbort, C. J.
Lindner, Andreas
Hanitsch, Leif Gunnar
Leistner, Rasmus
Schroeder, Jennyver-Tabea
von Bernuth, Horst
Stegemann, Miriam Songa
Schuermann, Mariana
Zychlinsky, Arturo
Krueger, Renate
Marsman, Gerben
JOURNAL OF LEUKOCYTE BIOLOGY, 2024, 115 (02) : 222 - 234
[27] IL-1R signaling enhances neutrophil extracellular traps (NETs) formation and leads to increase lung permeability and hypoxemia in LPS/mechanical ventilation-induced acute lung injury mouse model
Nosaka, Nobuyuki
Martinon, Daisy
Crother, Timothy R.
Arditi, Moshe
Shimada, Kenichi
JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
[28] The C-terminal region of the G-CSF receptor is required for induction of neutrophil elastase expression in myeloid cells:: Implication for understanding CSF3R mutations in acute myeloid leukemia evolving from severe congenital neutropenia.
Dong, Fan
Qiu, Yaling
Friedman, Alan D.
Liu, Qingquan
BLOOD, 2006, 108 (11) : 342A - 342A
[29] MYELOPEROXIDASE-DEFICIENT POLYMORPHONUCLEAR LEUKOCYTES - LONGITUDINAL-STUDY DURING THE PREREMISSION PHASE AND THE REMISSION PHASE IN ACUTE MYELOID-LEUKEMIA - COMPARISON TO NEUTROPHIL ALKALINE-PHOSPHATASE (NAP) ACTIVITY
BENDIXHANSEN, K
BLUT, 1986, 52 (04): : 237 - 242
[30] Prophylactic use of granulocyte colony-stimulating factor after induction chemotherapy in patients with newly diagnosed acute myeloid leukemia may increase the complete remission rate: a meta-analysis of five randomised controlled trials
Wang, Jing
Zhan, Ping
Ouyang, Jian
Chen, Bing
Zhou, Rongfu
LEUKEMIA & LYMPHOMA, 2009, 50 (03) : 457 - 459

← 1 2 3 →