DNA DAMAGE De-sanitizing tumour cells

被引：0
|
作者：
Alderton, Gemma K.
机构：
来源：
NATURE REVIEWS CANCER | 2014年 / 14卷 / 05期
关键词：
D O I：
10.1038/nrc3734
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Two papers find that targeting MTH1, an enzyme that prevents the incorporation of oxidized purine nucleotides into DNA, causes lethality in various tumour cell lines.
引用
收藏
页码：297 / 297
页数：1
相关论文
共 50 条
  • [41] SHEDDING OF SUB-LETHAL DAMAGE BY ANOXIC TUMOUR CELLS
    MCNALLY, NJ
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1971, 20 (02): : 193 - &
  • [42] Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
    Yiping He
    Jian Wu
    Devin C. Dressman
    Christine Iacobuzio-Donahue
    Sanford D. Markowitz
    Victor E. Velculescu
    Luis A. Diaz Jr
    Kenneth W. Kinzler
    Bert Vogelstein
    Nickolas Papadopoulos
    Nature, 2010, 464 : 610 - 614
  • [43] Heteroplasmic mitochondrial DNA mutations in normal and tumour cells
    He, Yiping
    Wu, Jian
    Dressman, Devin C.
    Iacobuzio-Donahue, Christine
    Markowitz, Sanford D.
    Velculescu, Victor E.
    Diaz, Luis A., Jr.
    Kinzler, Kenneth W.
    Vogelstein, Bert
    Papadopoulos, Nickolas
    NATURE, 2010, 464 (7288) : 610 - U175
  • [44] SUMOylation and de-SUMOylation in response to DNA damage
    Dou, Hong
    Huang, Chao
    Thang Van Nguyen
    Lu, Long-Sheng
    Yeh, Edward T. H.
    FEBS LETTERS, 2011, 585 (18) : 2891 - 2896
  • [45] INDUCTION OF CHROMOSOME STRUCTURAL DAMAGE IN EHRLICH ASCITES TUMOUR CELLS
    HAWES, C
    HOWARD, A
    GRAY, LH
    MUTATION RESEARCH, 1966, 3 (01): : 79 - &
  • [46] Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair
    Vrouwe, Mischa G.
    Elghalbzouri-Maghrani, Elhaam
    Meijers, Matty
    Schouten, Peter
    Godthelp, Barbara C.
    Bhuiyan, Zahurul A.
    Redeker, Egbert J.
    Mannens, Marcel M.
    Mullenders, Leon H. F.
    Pastink, Albert
    Darroudi, Firouz
    HUMAN MOLECULAR GENETICS, 2007, 16 (12) : 1478 - 1487
  • [47] DNA filter elution: A window on DNA damage in mammalian cells
    Kohn, KW
    BIOESSAYS, 1996, 18 (06) : 505 - 513
  • [48] Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase
    Skoufias, DA
    Lacroix, FB
    Andreassen, PR
    Wilson, L
    Margolis, RL
    MOLECULAR CELL, 2004, 15 (06) : 977 - 990
  • [49] The tumour suppressor CYLD regulates the p53 DNA damage response
    Fernandez-Majada, Vanesa
    Welz, Patrick-Simon
    Ermolaeva, Maria A.
    Schell, Michael
    Adam, Alexander
    Dietlein, Felix
    Komander, David
    Buettner, Reinhard
    Thomas, Roman K.
    Schumacher, Bjoern
    Pasparakis, Manolis
    NATURE COMMUNICATIONS, 2016, 7
  • [50] Tumour suppressors - Effect of DNA damage on a BRCA1 complex - Reply
    Li, S
    Ting, NSY
    Zheng, L
    Chen, PL
    Lee, WH
    NATURE, 2001, 414 (6859) : 36 - 36
12345