Two papers find that targeting MTH1, an enzyme that prevents the incorporation of oxidized purine nucleotides into DNA, causes lethality in various tumour cell lines.
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Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Div Protect Immun, Philadelphia, PA 19104 USA
Univ Penn, Cell & Mol Biol Grad Program, Perelman Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA
Pancholi, Neha J.
Price, Alexander M.
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机构:
Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Div Protect Immun, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA
Price, Alexander M.
Weitzman, Matthew D.
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机构:
Childrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA
Childrens Hosp Philadelphia, Div Protect Immun, Philadelphia, PA 19104 USA
Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USAChildrens Hosp Philadelphia, Div Canc Pathobiol, Philadelphia, PA 19104 USA