Mechanisms of rDNA Copy Number Maintenance

被引：67
|
作者：
Nelson, Jonathan O. [1 ,4 ]
Watase, George J. [1 ,4 ]
Warsinger-Pepe, Natalie [1 ,3 ]
Yamashita, Yukiko M. [1 ,2 ,4 ]
机构：
[1] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Cell & Dev Biol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA
来源：
TRENDS IN GENETICS | 2019年 / 35卷 / 10期
关键词：
RIBOSOMAL-RNA GENES; SISTER-CHROMATID EXCHANGE; SECONDARY STRUCTURE MAPS; NUCLEOLAR DOMINANCE; REPLICATION FORK; Y-CHROMOSOME; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; R2; RETROTRANSPOSITION; DNA METHYLATION;
D O I：
10.1016/j.tig.2019.07.006
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
rDNA, the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for ribosome biogenesis. rDNA genes are arranged in large stretches of tandem repeats, forming loci that are highly susceptible to copy loss due to their repetitiveness and active transcription throughout the cell cycle. Despite this inherent instability, rDNA copy number is generally maintained within a particular range in each species, pointing to the presence of mechanisms that maintain rDNA copy number in a homeostatic range. In this review, we summarize the current understanding of these maintenance mechanisms and how they sustain rDNA copy number throughout populations.
引用
收藏
页码：734 / 742
页数：9
相关论文
共 50 条
  • [31] Metal exposure causes rDNA copy number to fluctuate in mutation accumulation lines of Daphnia pulex
    Harvey, Eleanor F.
    Cristescu, Melania E.
    Dale, Jenna
    Hunter, Hailey
    Randall, Connor
    Crease, Teresa J.
    AQUATIC TOXICOLOGY, 2020, 226
  • [32] Copy Number Signatures Elucidate Mechanisms Underlying Sarcoma Heterogeneity
    Steele, C. D.
    Behjati, S.
    Amary, F.
    Tirabosco, R.
    Van Loo, P.
    Flanagan, A. M.
    Pillay, N.
    JOURNAL OF PATHOLOGY, 2018, 246 : S11 - S11
  • [33] Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae
    Ii, Miki
    Ii, Tatsuya
    Brill, Steven J.
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 625 (1-2) : 1 - 19
  • [34] MAINTENANCE OF COPY NUMBER OF RETRANSPOSON MDG3 IN DROSOPHILA-MELANOGASTER
    GLUSHKOVA, IV
    BELYAEVA, ES
    GVOZDEV, VA
    GENETIKA, 1991, 27 (03): : 404 - 410
  • [35] The rDNA unit of Encephalitozoon cuniculi (Microsporidia):: Complete 23S sequence and copy number.
    Biderre, C
    Peyretaillade, E
    Duffieux, F
    Peyret, P
    Metenier, G
    Vivares, C
    JOURNAL OF EUKARYOTIC MICROBIOLOGY, 1997, 44 (06) : 76S - 76S
  • [36] Reduced rDNA Copy Number Does Not Affect "Competitive" Chromosome Pairing in XYY Males of Drosophila melanogaster
    Maggert, Keith A.
    G3-GENES GENOMES GENETICS, 2014, 4 (03): : 497 - 507
  • [37] Spontaneous rDNA copy number variation modulates Sir2 levels and epigenetic gene silencing
    Michel, AH
    Kornmann, B
    Dubrana, K
    Shore, D
    GENES & DEVELOPMENT, 2005, 19 (10) : 1199 - 1210
  • [38] Mechanisms of copy number variants in neuropsychiatric disorders: From genes to therapeutics
    Forrest, Marc P.
    Penzes, Peter
    CURRENT OPINION IN NEUROBIOLOGY, 2023, 82
  • [39] Mutations and copy number alterations in diffuse gliomas are shaped by different mechanisms
    Ozduman, K.
    Ulgen, E.
    Karacan, S.
    Gerlevik, U.
    Can, O.
    Bilguvar, K.
    Akyerli, C. B.
    Yuksel, S. K.
    Ersen-Danyeli, A.
    Tihan, T.
    Yakicier, C.
    Sezerman, O. U.
    Pamir, M. N.
    EUROPEAN JOURNAL OF CANCER, 2020, 138 : S32 - S33
  • [40] MICRORNA MECHANISMS IMPLICATED BY RARE COPY NUMBER VARIANTS AND SCHIZOPHRENIA CAUSATION
    Bassett, Anne
    SCHIZOPHRENIA BULLETIN, 2015, 41 : S197 - S197
12345