Mechanisms of rDNA Copy Number Maintenance

被引：67

作者：

Nelson, Jonathan O. ^{[1
,4
]}

Watase, George J. ^{[1
,4
]}

Warsinger-Pepe, Natalie ^{[1
,3
]}

Yamashita, Yukiko M. ^{[1
,2
,4
]}

机构：

[1] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Cell & Dev Biol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

TRENDS IN GENETICS | 2019年 / 35卷 / 10期

关键词：

RIBOSOMAL-RNA GENES; SISTER-CHROMATID EXCHANGE; SECONDARY STRUCTURE MAPS; NUCLEOLAR DOMINANCE; REPLICATION FORK; Y-CHROMOSOME; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; R2; RETROTRANSPOSITION; DNA METHYLATION;

D O I：

10.1016/j.tig.2019.07.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

rDNA, the genes encoding the RNA components of ribosomes (rRNA), are highly repetitive in all eukaryotic genomes, containing 100s to 1000s of copies, to meet the demand for ribosome biogenesis. rDNA genes are arranged in large stretches of tandem repeats, forming loci that are highly susceptible to copy loss due to their repetitiveness and active transcription throughout the cell cycle. Despite this inherent instability, rDNA copy number is generally maintained within a particular range in each species, pointing to the presence of mechanisms that maintain rDNA copy number in a homeostatic range. In this review, we summarize the current understanding of these maintenance mechanisms and how they sustain rDNA copy number throughout populations.

引用

页码：734 / 742

页数：9

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