We hypothesized that exercise training would lead to enhanced endothelium-dependent vasodilation in porcine pulmonary arteries. Pulmonary artery rings (2- to 3-mm OD) were obtained from female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder). Exercise training was performed for 16 wk, and vasomotor responses were studied by using standard isometric techniques. Contractile responses to 80 mM KCl, isosmotic KCl (10-100 mM), and norepinephrine (10(-8) to 10(-4) M) did not differ between sedentary (Sed) and exercise-trained (Ex) pigs. Relaxation was assessed to endothelium-dependent and endothelium-independent vasodilators after norepinephrine contraction. Pulmonary arteries of Ex pigs exhibited greater maximal relaxation to ACh (61.9 +/- 3.5%) than did those of Sed pigs (52.3 +/- 3.9%; P < 0.05). Endothelium-independent relaxation to sodium nitroprusside did not differ. Inhibition of nitric oxide synthase significantly decreased acetylcholine-induced relaxation, with greater inhibition in arteries from Ex pigs (P < 0.05). Inhibition of cyclooxygenase enhanced relaxation to acetylcholine in arteries from Sed pigs. We conclude that exercise training enhances endothelium-dependent (ACh-mediated) vasorelaxation in pulmonary arteries by mechanisms of increased reliance on nitric oxide and reduced production of a prostanoid constrictor.
机构:
Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, OmanSultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, Oman
Al-Dhuhli, Farid
Al-Siyabi, Sultan
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Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, OmanSultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, Oman
Al-Siyabi, Sultan
Al-Maamari, Hamed
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Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, OmanSultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, Oman
Al-Maamari, Hamed
Al-Farsi, Said
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Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, OmanSultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, POB 35, Muscat 123, Oman
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Western Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Univ Ottawa, Dept Cellular & Mol Med, Fac Med, Ottawa, ON, CanadaWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
McDonald, Matthew W.
Olver, T. Dylan
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Univ Saskatchewan, Dept Vet Biomed Sci, Western Coll Vet Med, Saskatoon, SK, CanadaWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Olver, T. Dylan
Dotzert, Michelle S.
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Western Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, CanadaWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Dotzert, Michelle S.
Jurrissen, Thomas J.
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Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USAWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Jurrissen, Thomas J.
Noble, Earl G.
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Western Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Lawson Hlth Res Inst, London, ON, CanadaWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Noble, Earl G.
Padilla, Jaume
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Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA
Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA
Univ Missouri, Dept Child Hlth, Columbia, MO 65201 USAWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada
Padilla, Jaume
Melling, C. W. James
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Western Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, CanadaWestern Univ, Sch Kinesiol, Thames Hall Room 2213, London, ON N6A 3K7, Canada