Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs

被引:24
|
作者
Johnson, LR
Parker, JL
Laughlin, MH
机构
[1] Univ Missouri, Dept Vet Biomed Sci, Columbia, MO 65211 USA
[2] Texas A&M Univ, Dept Med Physiol, Ctr Hlth Sci, College Stn, TX 77843 USA
关键词
nitric oxide synthase; prostanoids; endothelium dependent; porcine; pulmonary circulation;
D O I
10.1152/jappl.2000.88.2.443
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We hypothesized that exercise training would lead to enhanced endothelium-dependent vasodilation in porcine pulmonary arteries. Pulmonary artery rings (2- to 3-mm OD) were obtained from female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder). Exercise training was performed for 16 wk, and vasomotor responses were studied by using standard isometric techniques. Contractile responses to 80 mM KCl, isosmotic KCl (10-100 mM), and norepinephrine (10(-8) to 10(-4) M) did not differ between sedentary (Sed) and exercise-trained (Ex) pigs. Relaxation was assessed to endothelium-dependent and endothelium-independent vasodilators after norepinephrine contraction. Pulmonary arteries of Ex pigs exhibited greater maximal relaxation to ACh (61.9 +/- 3.5%) than did those of Sed pigs (52.3 +/- 3.9%; P < 0.05). Endothelium-independent relaxation to sodium nitroprusside did not differ. Inhibition of nitric oxide synthase significantly decreased acetylcholine-induced relaxation, with greater inhibition in arteries from Ex pigs (P < 0.05). Inhibition of cyclooxygenase enhanced relaxation to acetylcholine in arteries from Sed pigs. We conclude that exercise training enhances endothelium-dependent (ACh-mediated) vasorelaxation in pulmonary arteries by mechanisms of increased reliance on nitric oxide and reduced production of a prostanoid constrictor.
引用
收藏
页码:443 / 451
页数:9
相关论文
共 50 条
  • [31] Moderate-Intensity Exercise Training Reduces Vasorelaxation of Mesenteric Arteries: Role of BKCa Channels and Nitric Oxide
    Al-Dhuhli, Farid
    Al-Siyabi, Sultan
    Al-Maamari, Hamed
    Al-Farsi, Said
    Albarwani, Sulayma
    PHYSIOLOGICAL RESEARCH, 2022, 71 (01) : 67 - 77
  • [32] Exercise training improves characteristics of exercise oscillatory ventilation in chronic heart failure
    Panagopoulou, Niki
    Karatzanos, Eleftherios
    Dimopoulos, Stavros
    Tasoulis, Athanasios
    Tachliabouris, Ioannis
    Vakrou, Styliani
    Sideris, Antonios
    Gratziou, Christina
    Nanas, Serafim
    EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2017, 24 (08) : 825 - 832
  • [33] Chronic obstructive pulmonary disease: exercise training on the edge
    Troosters, Thierry
    EXPERIMENTAL PHYSIOLOGY, 2013, 98 (06) : 1079 - 1080
  • [34] Aerobic exercise training improves insulin-induced vasorelaxation in a vessel-specific manner in rats with insulin-treated experimental diabetes
    McDonald, Matthew W.
    Olver, T. Dylan
    Dotzert, Michelle S.
    Jurrissen, Thomas J.
    Noble, Earl G.
    Padilla, Jaume
    Melling, C. W. James
    DIABETES & VASCULAR DISEASE RESEARCH, 2019, 16 (01): : 77 - 86
  • [35] Exercise training in chronic obstructive pulmonary disease.
    Sivori, M
    Rhodius, E
    Kaplan, P
    Talarico, M
    Gorojod, G
    Carreras, B
    Lopez, C
    Shimojo, C
    MEDICINA-BUENOS AIRES, 1998, 58 (06) : 717 - 727
  • [36] Effect of exercise training on resistance arteries in rats with chronic NOS inhibition
    Kuru, Oktay
    Senturk, Umit Kemal
    Kocer, Guennur
    Ozdem, Sadi
    Baskurt, Oguz K.
    Cetin, Arzu
    Yesilkaya, Akin
    Gunduz, Filiz
    JOURNAL OF APPLIED PHYSIOLOGY, 2009, 107 (03) : 896 - 902
  • [37] Isometric Handgrip Exercise Training Improves Spirometric Parameters and Pulmonary Capacity
    Godsday, Ogbutor Udoji
    Kingsley, Nwangwa Eze
    Chukwuebuka, Nwogueze Bartholomew
    Ephraim, Chukwuemeka
    Emmanuel, Ezunu
    Ejime, Agbonifo-Chijiokwu
    Chukwuka, Igweh John
    PATHOPHYSIOLOGY, 2021, 28 (03) : 328 - 338
  • [38] Tadalafil Improves Exercise Induced Pulmonary Arterial Hypertension in a Patient With Chronic Altitude-Related Illness
    Jimenez, G.
    Mcguire, W. C.
    Orr, J. E.
    Fernandes, T. M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [39] EXERCISE TRAINING DURING PULMONARY REHABILITATION IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
    DEKHUIJZEN, PNR
    VANHERWAARDEN, CLA
    COX, NJM
    FOLGERING, HTM
    LUNG, 1990, 168 : 481 - 488
  • [40] Exercise Training After Pulmonary Endarterectomy for Patients with Chronic Thromboembolic Pulmonary Hypertension
    La Rovere, Maria Teresa
    Pinna, Gian Domenico
    Pin, Maurizio
    Bruschi, Claudio
    Callegari, Giovanna
    Zanotti, Ercole
    D'Armini, Andrea
    Ambrosino, Nicolino
    RESPIRATION, 2019, 97 (03) : 234 - 241