Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs

被引:24
|
作者
Johnson, LR
Parker, JL
Laughlin, MH
机构
[1] Univ Missouri, Dept Vet Biomed Sci, Columbia, MO 65211 USA
[2] Texas A&M Univ, Dept Med Physiol, Ctr Hlth Sci, College Stn, TX 77843 USA
关键词
nitric oxide synthase; prostanoids; endothelium dependent; porcine; pulmonary circulation;
D O I
10.1152/jappl.2000.88.2.443
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We hypothesized that exercise training would lead to enhanced endothelium-dependent vasodilation in porcine pulmonary arteries. Pulmonary artery rings (2- to 3-mm OD) were obtained from female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder). Exercise training was performed for 16 wk, and vasomotor responses were studied by using standard isometric techniques. Contractile responses to 80 mM KCl, isosmotic KCl (10-100 mM), and norepinephrine (10(-8) to 10(-4) M) did not differ between sedentary (Sed) and exercise-trained (Ex) pigs. Relaxation was assessed to endothelium-dependent and endothelium-independent vasodilators after norepinephrine contraction. Pulmonary arteries of Ex pigs exhibited greater maximal relaxation to ACh (61.9 +/- 3.5%) than did those of Sed pigs (52.3 +/- 3.9%; P < 0.05). Endothelium-independent relaxation to sodium nitroprusside did not differ. Inhibition of nitric oxide synthase significantly decreased acetylcholine-induced relaxation, with greater inhibition in arteries from Ex pigs (P < 0.05). Inhibition of cyclooxygenase enhanced relaxation to acetylcholine in arteries from Sed pigs. We conclude that exercise training enhances endothelium-dependent (ACh-mediated) vasorelaxation in pulmonary arteries by mechanisms of increased reliance on nitric oxide and reduced production of a prostanoid constrictor.
引用
收藏
页码:443 / 451
页数:9
相关论文
共 50 条
  • [21] Exercise training improves endothelial function in resistance arteries of young prehypertensives
    D T Beck
    J S Martin
    D P Casey
    R W Braith
    Journal of Human Hypertension, 2014, 28 : 303 - 309
  • [22] Exercise training improves endothelial function in resistance arteries of young prehypertensives
    Beck, D. T.
    Martin, J. S.
    Casey, D. P.
    Braith, R. W.
    JOURNAL OF HUMAN HYPERTENSION, 2014, 28 (05) : 303 - 309
  • [23] Endothelial cell membrane cholesterol content regulates the contribution of TRPV4 channels in ACh-induced vasodilation in rat gracilis arteries
    Morin, Emily E.
    Salbato, Sophia
    Walker, Benjimen R.
    Naik, Jay S.
    MICROCIRCULATION, 2022, 29 (4-5)
  • [24] Exercise training improves endothelium mediated relaxation responses of resistance arteries isolated distal to chronic coronary occlusion
    Griffin, KL
    Laughlin, MH
    Parker, JL
    CIRCULATION, 1997, 96 (08) : 1729 - 1729
  • [25] Exercise training in chronic obstructive pulmonary disease
    Rochester, CL
    JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT, 2003, 40 (05): : 59 - 80
  • [26] Exercise training in chronic obstructive pulmonary disease
    Bourjeily, G
    Rochester, CL
    CLINICS IN CHEST MEDICINE, 2000, 21 (04) : 763 - +
  • [27] Exercise training restores adenosine-induced relaxation in coronary arteries distal to chronic occlusion
    Heaps, CL
    Sturek, M
    Rapps, JA
    Laughlin, MH
    Parker, JL
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 278 (06): : H1984 - H1992
  • [28] Pulmonary Rehabilitation and Exercise Training in Chronic Obstructive Pulmonary Disease
    Gloeckl, Rainer
    Schneeberger, Tessa
    Jarosch, Inga
    Kenn, Klaus
    DEUTSCHES ARZTEBLATT INTERNATIONAL, 2018, 115 (08): : 117 - +
  • [29] Supervised exercise training improves exercise cardiovascular function in idiopathic pulmonary fibrosis
    Vainshelboim, Baruch
    Kramer, Mordechai R.
    Fox, Benjamin D.
    Izhakian, Shimon
    Sagie, Alexander
    Oliveira, Jose
    EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE, 2017, 53 (02) : 209 - 218
  • [30] Exercise training improves aging-induced KCa channel down regulation in rat's coronary arteries
    Albarwani, Sulayma Amur
    Al-Siyabi, Sultan
    Ba-Omar, Hajer
    Hassan, Mohammed O.
    FASEB JOURNAL, 2007, 21 (06): : A1382 - A1383