Highly Enantioselective Synthesis of Alkylpyridine Derivatives through a Michael/Michael/Aldol Cascade Reaction

被引：8
|
作者：
Meazza, Marta [1 ]
Potter, Michael [1 ]
Pitak, Mateusz B. [2 ]
Coles, Simon J. [2 ]
Mazzanti, Andrea [3 ]
Rios, Ramon [1 ]
机构：
[1] Univ Southampton, Sch Chem, Southampton, Hants, England
[2] Univ Southampton, Sch Chem, UK Natl Crystallog Serv, Southampton, Hants, England
[3] Univ Bologna, Sch Sci, Dept Ind Chem Toso Montanari, Viale Risorgimento 4, I-40136 Bologna, Italy
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 03期
基金：
英国工程与自然科学研究理事会;
关键词：
Domino reactions; Enantioselectivity; Michael addition; Nitrogen heterocycles; Organocatalysis; ORGANOCATALYTIC DOMINO REACTIONS; CATALYSIS; HETEROCYCLES; ENALS;
D O I：
10.1002/ejoc.201601491
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the synthesis of pyridine derivatives based on a triple cascade reaction catalyzed by chiral secondary amines was developed. The resulting cyclohexenes (three C-C bonds were formed) were obtained in good yields with good diastereoselectivities and excellent enantioselectivities.
引用
收藏
页码：719 / 725
页数：7
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