Highly efficient synthesis of enantioenriched fully-substituted spirocyclohexane oxindoles via a Michael-Michael-aldol cascade reaction

被引：15
|
作者：
Sun, Qiang-Sheng [1 ]
Lin, Hua [2 ]
Sun, Xun [2 ]
Sun, Xing-Wen [1 ,3 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China
[3] Chinese Acad Sci, Key Lab Synthet & Self Assembly Chem Organ Funct, Beijing 100864, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 50期
基金：
中国国家自然科学基金;
关键词：
Michael-Michael-aldol; Cascade reaction; Organocatalysis; Spirooxindole; Quaternary stereocenter; QUATERNARY CARBON CENTERS; ASYMMETRIC ORGANOCATALYTIC SYNTHESIS; N-HETEROCYCLIC CARBENE; DOMINO REACTIONS; ENANTIOSELECTIVE CONSTRUCTION; NATURAL-PRODUCTS; STEREOCENTERS; DERIVATIVES; CATALYSIS; POTENT;
D O I：
10.1016/j.tetlet.2016.11.019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient organocatalyzed Michael-Michael-aldol cascade reaction for the construction of enantioenriched spirocyclohexane oxindoles bearing six consecutive stereocenters, up to three quaternary stereocenters, including two consecutive quaternary stereocenters has been achieved in good yields with excellent stereoselectivities under mild conditions. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5673 / 5676
页数：4
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