Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis

被引：1

作者：

Dai, Yihua ^{[1
]}

Shen, Yanfeng ^{[1
]}

Gao, Shuanhu ^{[1
,2
]}

机构：

[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

[2] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 07期

基金：

中国国家自然科学基金;

关键词：

halo-michael/aldol reaction; cascade reaction; Lewis acid; application; synthesis; BAYLIS-HILLMAN REACTION; ENANTIOSELECTIVE TOTAL-SYNTHESIS; Z/E STEREOSELECTIVE-SYNTHESIS; ALDOL REACTION; ALPHA; BETA-ACETYLENIC KETONES; TITANIUM(IV) CHLORIDE; ASYMMETRIC-SYNTHESIS; BIOLOGICAL EVALUATION; STRUCTURAL REVISION; PAF ANTAGONISTS;

D O I：

10.6023/cjoc201803005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition and aldol reaction are among the most basic and commoly used reactions. Cascade halo-Michael/Aldol reaction can effectively improve the atomic economy and step economy of organic synthesis. After the Michael addition of alpha,beta-unsaturated compound with halide ion (Cl-, Br-, I-), the reactive intermediate reacts with aldehyde through aldol reaction in the same reaction system. This process is called cascade halo-Michael/Aldol reaction. The cascade halo-Michael/Aldol reaction and its applications in the synthesis of related compounds according to the types of Lewis acid are introduced.

引用

页码：1608 / 1625

页数：18

共 79 条

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