Risk Factors of Transition from Normal Cognition to Mild Cognitive Disorder: The PATH through Life Study

被引：73
|
作者：
Cherbuin, Nicolas [1 ]
Reglade-Meslin, Chantal [1 ]
Kumar, Rajeev [1 ,2 ]
Jacomb, Patricia [1 ]
Easteal, Simon [3 ]
Christensen, Helen [1 ]
Sachdev, Perminder [4 ,5 ]
Anstey, Kaarin J. [1 ]
机构：
[1] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT 0200, Australia
[2] Australian Natl Univ, Dept Psychol Med, Canberra, ACT 0200, Australia
[3] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
[4] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia
[5] Inst Neuropsychiat, Sydney, NSW, Australia
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 28卷 / 01期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Mild cognitive impairment; Alcohol; Hypertension; BMI; Depression; IDENTIFICATION TEST AUDIT; ALZHEIMERS-DISEASE; ALCOHOL-CONSUMPTION; COMMUNITY SAMPLE; BLOOD-PRESSURE; TOTAL HEALTH; IMPAIRMENT; DEMENTIA; PROGRESSION; PERSONALITY;
D O I：
10.1159/000229025
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community. Copyright (c) 2009 S. Karger AG, Basel
引用
收藏
页码：47 / 55
页数：9
相关论文
共 50 条
  • [21] Diabetes and Prediabetes Inhibit Reversion from Mild Cognitive Impairment to Normal Cognition
    Makino, Keitaro
    Lee, Sangyoon
    Bae, Seongryu
    Chiba, Ippei
    Harada, Kenji
    Katayama, Osamu
    Shinkai, Yohei
    Makizako, Hyuma
    Shimada, Hiroyuki
    [J]. JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2021, 22 (09) : 1912 - +
  • [22] Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi-state Markov models
    Sanz-Blasco, Ruben
    Ruiz-Sanchez de Leon, Jose M.
    Avila-Villanueva, Marina
    Valenti-Soler, Meritxel
    Gomez-Ramirez, Jaime
    Fernandez-Blazquez, Miguel A.
    [J]. ALZHEIMERS & DEMENTIA, 2022, 18 (06) : 1177 - 1185
  • [23] Relationships Between Cognitive Complaints and Quality of Life in Older Adults With Mild Cognitive Impairment, Mild Alzheimer Disease Dementia, and Normal Cognition
    Stites, Shana D.
    Harkins, Kristin
    Rubright, Jonathan D.
    Karlawish, Jason
    [J]. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2018, 32 (04): : 276 - 283
  • [24] Risk factors for mild cognitive impairment in a population study
    Lopez, OL
    Jagust, WW
    DeKosky, ST
    Becker, JT
    Fitzpatrick, A
    [J]. NEUROLOGY, 2002, 58 (07) : A238 - A238
  • [25] Comparative Study of Risk Factors Associated with Normal Cognition and Cognitive Impairment in Rural West Elderly Texans
    Khan, Hafiz
    Farhana, Fardous
    Mostafa, Fahad
    Rafiq, Aamrin
    Nizia, Effat Walia
    Razzaq, Refaya
    Atique, Rumana
    Dauenhauer, Megan
    Zabin, Zawah
    Palle, Komaraiah
    Reddy, P. Hemachandra
    [J]. JOURNAL OF ALZHEIMERS DISEASE REPORTS, 2024, 8 (01) : 1133 - 1151
  • [26] Risk factors for incident mild cognitive impairment - results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
    Luck, T.
    Riedel-Heller, S. G.
    Luppa, M.
    Wiese, B.
    Wollny, A.
    Wagner, M.
    Bickel, H.
    Weyerer, S.
    Pentzek, M.
    Haller, F.
    Moesch, E.
    Werle, J.
    Eisele, M.
    Maier, W.
    van den Bussche, H.
    Kaduszkiewicz, H.
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 2010, 121 (04) : 260 - 272
  • [27] Estimating Alzheimer's Disease Progression Rates from Normal Cognition Through Mild Cognitive Impairment and Stages of Dementia
    Davis, Matthew
    O'Connell, Thomas
    Johnson, Scott
    Cline, Stephanie
    Merikle, Elizabeth
    Martenyi, Ferenc
    Simpson, Kit
    [J]. CURRENT ALZHEIMER RESEARCH, 2018, 15 (08) : 777 - 788
  • [28] Attention Deficit/Hyperactivity Disorder Symptoms and Cognitive Abilities in the Late-Life Cohort of the PATH through Life Study
    Das, Debjani
    Cherbuin, Nicolas
    Easteal, Simon
    Anstey, Kaarin J.
    [J]. PLOS ONE, 2014, 9 (01):
  • [29] The impact of mild cognitive impairment on decision-making under explicit risk conditions: Evidence from the Personality and Total Health (PATH) Through Life longitudinal study
    Sinclair, Craig
    Eramudugolla, Ranmalee
    Cherbuin, Nicolas
    Mortby, Moyra E.
    Anstey, Kaarin J.
    [J]. JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2023, 29 (06) : 594 - 604
  • [30] Reversible predictors of reversion from mild cognitive impairment to normal cognition: a 4-year longitudinal study
    Hiroyuki Shimada
    Takehiko Doi
    Sangyoon Lee
    Hyuma Makizako
    [J]. Alzheimer's Research & Therapy, 11
12345