Multifrequency magnetic resonance elastography of the brain reveals tissue degeneration in neuromyelitis optica spectrum disorder

被引：15

作者：

Streitberger, Kaspar-Josche ^{[1
,2
]}

Fehlner, Andreas ^{[1
]}

Pache, Florence ^{[2
,3
]}

Lacheta, Anna ^{[3
]}

Papazoglou, Sebastian ^{[3
]}

Bellmann-Strobl, Judith ^{[4
,5
]}

Ruprecht, Klemens ^{[2
]}

Brandt, Alexander ^{[3
]}

Braun, Juergen ^{[6
]}

Sack, Ingolf ^{[1
]}

Paul, Friedemann ^{[2
,3
,4
,5
]}

Wuerfel, Jens ^{[3
,4
,5
,7
]}

机构：

[1] Charite Univ Med Berlin, Dept Radiol, Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Neurol Expt Neurol, Charitepl 1, D-10117 Berlin, Germany

[3] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Charitepl 1, D-10117 Berlin, Germany

[4] Max Delbrueck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany

[5] Charite Univ Med Berlin, Berlin, Germany

[6] Charite Univ Med Berlin, Inst Med Informat, Hindenburgdamm 30, D-12203 Berlin, Germany

[7] Med Image Anal Ctr MIAC AG, Basel, Switzerland

来源：

EUROPEAN RADIOLOGY | 2017年 / 27卷 / 05期

关键词：

Multifrequency magnetic resonance elastography; MMRE; MDEV inversion; Brain tissue; Neuromyelitis optica; VISCOELASTIC PROPERTIES; MULTIPLE-SCLEROSIS; MR ELASTOGRAPHY; DIAGNOSTIC-CRITERIA; DISEASE; AQUAPORIN-4; ANTIBODIES; PRESSURE;

D O I：

10.1007/s00330-016-4561-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Application of multifrequency magnetic resonance elastography (MMRE) of the brain parenchyma in patients with neuromyelitis optica spectrum disorder (NMOSD) compared to age matched healthy controls (HC). 15 NMOSD patients and 17 age- and gender-matched HC were examined using MMRE. Two three-dimensional viscoelastic parameter maps, the magnitude |G*| and phase angle phi of the complex shear modulus were reconstructed by simultaneous inversion of full wave-field data in 1.9-mm isotropic resolution at 7 harmonic drive frequencies from 30 to 60 Hz. In NMOSD patients, a significant reduction of |G*| was observed within the white matter fraction (p = 0.017), predominantly within the thalamic regions (p = 0.003), compared to HC. These parameters exceeded the reduction in brain volume measured in patients versus HC (p = 0.02 whole-brain volume reduction). Volumetric differences in white matter fraction and the thalami were not detectable between patients and HC. However, phase angle phi was decreased in patients within the white matter (p = 0.03) and both thalamic regions (p = 0.044). MMRE reveals global tissue degeneration with accelerated softening of the brain parenchyma in patients with NMOSD. The predominant reduction of stiffness is found within the thalamic region and related white matter tracts, presumably reflecting Wallerian degeneration. aEuro cent Magnetic resonance elastography reveals diffuse cerebral tissue changes in patients with NMOSD. aEuro cent Premature tissue softening in NMOSD patients indicates tissue degeneration. aEuro cent Hypothesis of a widespread cerebral neurodegeneration in form of diffuse tissue alteration.

引用

页码：2206 / 2215

页数：10

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