Intravenous immunoglobulin as sole therapy for systemic vasculitis

被引:0
|
作者
Jayne, DRW [1 ]
Lockwood, CM [1 ]
机构
[1] UNIV CAMBRIDGE,SCH CLIN MED,DEPT MED,CAMBRIDGE CB2 1TN,ENGLAND
来源
BRITISH JOURNAL OF RHEUMATOLOGY | 1996年 / 35卷 / 11期
关键词
IVIg; ANCA; systemic vasculitis; Wegener's granulomatosis; microscopic polyangiitis;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
High-dose, pooled, i.v. immunoglobulin (IVIg) is a potential, alternative treatment for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) which has shown promise in the treatment of refractory disease when administered with continuing immunosuppression. This study of six new patients with antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis and early disease, without threatened vital organ function, examined the therapeutic response to treatment with IVIg alone. IVIg was well tolerated and all six patients had early reductions in disease activity. Four entered full, clinical remission which lasted for at least 1 yr, while in two the responses were partial and transient, and they subsequently required conventional treatment. After 16-48 months of follow-up, two of the four patients in full remission relapsed, but the other two have remained well.
引用
收藏
页码:1150 / 1153
页数:4
相关论文
共 50 条
  • [41] High dose intravenous immunoglobulin therapy in therapy-restistent ANCA-negative necrotizing vasculitis
    Altmeyer, P
    Seifarth, D
    Bacharach-Buhles, M
    HAUTARZT, 1999, 50 (12): : 853 - 858
  • [42] New treatment strategies for systemic vasculitis: The role of intravenous immune globulin therapy
    Lockwood, CM
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 104 : 77 - 82
  • [43] TREATMENT OF ANTINEUTROPHIL CYTOPLASMIC ANTIBODY (ANCA)-ASSOCIATED SYSTEMIC VASCULITIS WITH HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN
    RICHTER, C
    SCHNABEL, A
    CSERNOK, E
    DEGROOT, K
    REINHOLDKELLER, E
    GROSS, WL
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1995, 101 (01): : 2 - 7
  • [44] Intravenous immunoglobulin treatment in vasculitis and connective tissue disorders
    Andreas Steinbrecher
    Peter Berlit
    Journal of Neurology, 2006, 253 : v39 - v49
  • [45] Intravenous immunoglobulin treatment in vasculitis and connective tissue disorders
    Steinbrecher, Andreas
    Berlit, Peter
    JOURNAL OF NEUROLOGY, 2006, 253 (Suppl 5) : 39 - 49
  • [46] Intravenous immunoglobulin in livedo vasculitis: A new treatment option?
    Schanz, S
    Ulmer, A
    Fierlbeck, G
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 49 (03) : 555 - 556
  • [47] Monthly intravenous immunoglobulin for refractory intestinal IgA vasculitis
    Shimizu, Masaki
    Irabu, Hitoshi
    Shimbo, Asami
    Kaneko, Shuya
    Mori, Masaaki
    PEDIATRICS INTERNATIONAL, 2023, 65 (01)
  • [48] High dose intravenous immunoglobulin therapy in therapy-resistant ANCA-negative necrotizing vasculitis -: Comment
    Krämer, KU
    Balda, BR
    HAUTARZT, 2000, 51 (07): : 524 - 526
  • [49] Sustained benefit from intravenous immunoglobulin therapy for gastrointestinal involvement in systemic sclerosis
    Raja, Jasmin
    Nihtyanova, Svetlana I.
    Murray, Charles D.
    Denton, Christopher P.
    Ong, Voon H.
    RHEUMATOLOGY, 2016, 55 (01) : 115 - 119
  • [50] SUBCUTANEOUS IMMUNOGLOBULIN REPLACEMENT THERAPY IN AN ADULT WITH REPEATED SYSTEMIC REACTIONS TO INTRAVENOUS APPLICATIONS
    Estokova, Tatiana
    Ciznar, Peter
    Kovacova, Zuzana
    JOURNAL OF CLINICAL IMMUNOLOGY, 2014, 34 (06) : 728 - 729