Intravenous immunoglobulin as sole therapy for systemic vasculitis

被引:0
|
作者
Jayne, DRW [1 ]
Lockwood, CM [1 ]
机构
[1] UNIV CAMBRIDGE,SCH CLIN MED,DEPT MED,CAMBRIDGE CB2 1TN,ENGLAND
来源
BRITISH JOURNAL OF RHEUMATOLOGY | 1996年 / 35卷 / 11期
关键词
IVIg; ANCA; systemic vasculitis; Wegener's granulomatosis; microscopic polyangiitis;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
High-dose, pooled, i.v. immunoglobulin (IVIg) is a potential, alternative treatment for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) which has shown promise in the treatment of refractory disease when administered with continuing immunosuppression. This study of six new patients with antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis and early disease, without threatened vital organ function, examined the therapeutic response to treatment with IVIg alone. IVIg was well tolerated and all six patients had early reductions in disease activity. Four entered full, clinical remission which lasted for at least 1 yr, while in two the responses were partial and transient, and they subsequently required conventional treatment. After 16-48 months of follow-up, two of the four patients in full remission relapsed, but the other two have remained well.
引用
收藏
页码:1150 / 1153
页数:4
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