Pediatric High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas

被引：63

作者：

Fangusaro, Jason ^{[1
]}

机构：

[1] Childrens Mem Hosp, Dept Hematol Oncol Stem Cell Transplantat, Chicago, IL 60614 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2009年 / 24卷 / 11期

关键词：

high-grade glioma; diffuse intrinsic pontine glioma; brainstem; glioblastoma; BRAIN-STEM GLIOMAS; BONE-MARROW RESCUE; CONGENITAL GLIOBLASTOMA-MULTIFORME; PRIMITIVE NEUROECTODERMAL TUMORS; CHILDHOOD MALIGNANT GLIOMAS; CENTRAL-NERVOUS-SYSTEM; RANDOMIZED PHASE-III; RADIATION-THERAPY; MYELOABLATIVE CHEMOTHERAPY; NEUROFIBROMATOSIS TYPE-1;

D O I：

10.1177/0883073809338960

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas. they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.

引用

页码：1409 / 1417

页数：9

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