Pediatric High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas

被引：63
|
作者：
Fangusaro, Jason [1 ]
机构：
[1] Childrens Mem Hosp, Dept Hematol Oncol Stem Cell Transplantat, Chicago, IL 60614 USA
来源：
JOURNAL OF CHILD NEUROLOGY | 2009年 / 24卷 / 11期
关键词：
high-grade glioma; diffuse intrinsic pontine glioma; brainstem; glioblastoma; BRAIN-STEM GLIOMAS; BONE-MARROW RESCUE; CONGENITAL GLIOBLASTOMA-MULTIFORME; PRIMITIVE NEUROECTODERMAL TUMORS; CHILDHOOD MALIGNANT GLIOMAS; CENTRAL-NERVOUS-SYSTEM; RANDOMIZED PHASE-III; RADIATION-THERAPY; MYELOABLATIVE CHEMOTHERAPY; NEUROFIBROMATOSIS TYPE-1;
D O I：
10.1177/0883073809338960
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas. they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.
引用
收藏
页码：1409 / 1417
页数：9
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