Iodine Catalyzed One-Pot Multicomponent Synthesis of a Library of Compounds Containing Tetrazolo[1,5-a]pyrimidine Core

被引：76
|
作者：
Zeng, Li-Yan [1 ]
Cai, Chun [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Peoples R China
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 01期
关键词：
MOLECULAR-IODINE; CYCLOCONDENSATION; TAUTOMERISM; SYSTEM;
D O I：
10.1021/cc9000983
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Versatile and novel reactions of 5-aminotetrazole with structurally diverse aryl aldehydes and building blocks with active methylene catalyzed by iodine were investigated in a multicomponent one-pot protocol. A series of 5,7-diaryl-4,7-dihydrotetrazolo[1,5-a]pyrimidines C and 5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates D were obtained in moderate to good yields. Further exploration rapidly afforded various E in good to excellent yields; in addition, compound F was also obtained under the same condition. The Structures of products were characterized by LC-MS, H-1 NMR, C-13 NMR, and elemental analysis.
引用
收藏
页码：35 / 40
页数：6
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