Iodine Catalyzed One-Pot Multicomponent Synthesis of a Library of Compounds Containing Tetrazolo[1,5-a]pyrimidine Core

被引：76

作者：

Zeng, Li-Yan ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Chem Engn Coll, Nanjing 210094, Peoples R China

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 01期

关键词：

MOLECULAR-IODINE; CYCLOCONDENSATION; TAUTOMERISM; SYSTEM;

D O I：

10.1021/cc9000983

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Versatile and novel reactions of 5-aminotetrazole with structurally diverse aryl aldehydes and building blocks with active methylene catalyzed by iodine were investigated in a multicomponent one-pot protocol. A series of 5,7-diaryl-4,7-dihydrotetrazolo[1,5-a]pyrimidines C and 5-methyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylates D were obtained in moderate to good yields. Further exploration rapidly afforded various E in good to excellent yields; in addition, compound F was also obtained under the same condition. The Structures of products were characterized by LC-MS, H-1 NMR, C-13 NMR, and elemental analysis.

引用

页码：35 / 40

页数：6

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