The aim of this study was to investigate the effect of unilateral limb pain on sensitivity to pain on each side of the forehead. In the first experiment, pressure-pain thresholds and sharpness sensations were assessed on each side of the forehead in 45 healthy volunteers before and after a 10 degrees C cold pressor of the hand and in 18 controls who were not subjected to the cold pressor. In a second experiment, forehead sensitivity was assessed in 32 healthy volunteers before and after a 2 degrees C cold pressor. The assessments were repeated without the cold pressor, and before and after six successive 4 degrees C cold pressor tests. The 10 degrees C cold pressor did not influence forehead sensitivity, whereas the 2 degrees C cold pressor and the 4 degrees C cold pressor tests resulted in bilateral analgesia to sharpness and pressure. The analgesia to pressure was greater in the ipsilateral forehead. Stress-induced analgesia and diffuse noxious inhibitory controls may have contributed to the analgesia to pressure-pain and sharpness sensations bilaterally after the most painful cold pressor tests. The locus coeruleus inhibits ipsilateral nociceptive activity in dorsal horn neurons during limb inflammation, and thus may have mediated the ipsilateral component of analgesia. Pain-evoked changes in forehead sensitivity differed for sharpness and pressure, possibly due to separate thalamic or cortical representations of cutaneous and deep tissue sensibility. These findings suggest that several mechanisms act concurrently to influence pain sensitivity at sites distant from a primary site of painful stimulation. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
机构:
Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USAUniv Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Wasserman, Ronald A.
Hassett, Afton L.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Hassett, Afton L.
Harte, Steven E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Harte, Steven E.
Goesling, Jenna
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Goesling, Jenna
Malinoff, Herbert L.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Malinoff, Herbert L.
Berland, Daniel W.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Berland, Daniel W.
Zollars, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Zollars, Jennifer
Moser, Stephanie E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
Moser, Stephanie E.
Brummett, Chad M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Back & Pain Ctr, Burlington Bldg 1,Floor 1,325 E Eisenhower Pkwy, Ann Arbor, MI 48108 USA
机构:
Univ Newcastle Upon Tyne, Wolfson Unit Clin Pharmacol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, EnglandUniv Newcastle Upon Tyne, Wolfson Unit Clin Pharmacol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
Webb, J
Kamali, F
论文数: 0引用数: 0
h-index: 0
机构:
Univ Newcastle Upon Tyne, Wolfson Unit Clin Pharmacol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, EnglandUniv Newcastle Upon Tyne, Wolfson Unit Clin Pharmacol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England