Cold-induced limb pain decreases sensitivity to pressure-pain sensations in the ipsilateral forehead

被引:27
|
作者
Knudsen, Lone [1 ]
Drummond, Peter D. [1 ]
机构
[1] Murdoch Univ, Sch Psychol, Murdoch, WA 6150, Australia
关键词
Locus coeruleus; Diffuse noxious inhibitory controls; Stress-induced analgesia; Complex regional pain syndrome; Pain laterality; NOXIOUS INHIBITORY CONTROLS; REFLEX SYMPATHETIC DYSTROPHY; UNILATERAL HINDPAW INFLAMMATION; CONDITIONING STIMULATION HNCS; STRESS-INDUCED ANALGESIA; HORN CONVERGENT NEURONS; NUCLEUS LOCUS-COERULEUS; SPRAGUE-DAWLEY RATS; DORSAL-HORN; SPINAL-CORD;
D O I
10.1016/j.ejpain.2008.12.005
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The aim of this study was to investigate the effect of unilateral limb pain on sensitivity to pain on each side of the forehead. In the first experiment, pressure-pain thresholds and sharpness sensations were assessed on each side of the forehead in 45 healthy volunteers before and after a 10 degrees C cold pressor of the hand and in 18 controls who were not subjected to the cold pressor. In a second experiment, forehead sensitivity was assessed in 32 healthy volunteers before and after a 2 degrees C cold pressor. The assessments were repeated without the cold pressor, and before and after six successive 4 degrees C cold pressor tests. The 10 degrees C cold pressor did not influence forehead sensitivity, whereas the 2 degrees C cold pressor and the 4 degrees C cold pressor tests resulted in bilateral analgesia to sharpness and pressure. The analgesia to pressure was greater in the ipsilateral forehead. Stress-induced analgesia and diffuse noxious inhibitory controls may have contributed to the analgesia to pressure-pain and sharpness sensations bilaterally after the most painful cold pressor tests. The locus coeruleus inhibits ipsilateral nociceptive activity in dorsal horn neurons during limb inflammation, and thus may have mediated the ipsilateral component of analgesia. Pain-evoked changes in forehead sensitivity differed for sharpness and pressure, possibly due to separate thalamic or cortical representations of cutaneous and deep tissue sensibility. These findings suggest that several mechanisms act concurrently to influence pain sensitivity at sites distant from a primary site of painful stimulation. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1023 / 1029
页数:7
相关论文
共 50 条
  • [21] INDOMETHACIN - EFFECTS ON COLD-INDUCED PAIN AND THE NERVOUS-SYSTEM IN HEALTHY-VOLUNTEERS
    TELEKES, A
    HOLLAND, RL
    PECK, AW
    PAIN, 1987, 30 (03) : 321 - 328
  • [22] Hyperosmolar Tears Enhance Cooling Sensitivity of the Corneal Nerves in Rats: Possible Neural Basis for Cold-Induced Dry Eye Pain
    Hirata, Harumitsu
    Rosenblatt, Mark I.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (09) : 5821 - 5833
  • [23] Analgesia to pressure–pain develops in the ipsilateral forehead after high- and low-frequency electrical stimulation of the forearm
    Lechi Vo
    Peter D. Drummond
    Experimental Brain Research, 2014, 232 : 685 - 693
  • [24] CENTRAL SUPPRESSION OF COLD-INDUCED C-FIBER PAIN BY MYELINATED FIBER INPUT
    WAHREN, LK
    TOREBJORK, E
    JORUM, E
    PAIN, 1989, 38 (03) : 313 - 319
  • [25] Changes in cold-induced vasodilatation, pain and cold sensation in fingers caused by repeated finger cooling in a cool environment
    Sawada, S
    Araki, S
    Yokoyama, K
    INDUSTRIAL HEALTH, 2000, 38 (01) : 79 - 86
  • [26] Associations between pain thresholds for heat, cold and pressure, and Pain Sensitivity Questionnaire scores in healthy women and in women with persistent pelvic pain
    Grundstroem, Hanna
    Larsson, Britt
    Arendt-Nielsen, Lars
    Gerdle, Bjorn
    Kjolhede, Preben
    EUROPEAN JOURNAL OF PAIN, 2019, 23 (09) : 1631 - 1639
  • [27] CHANGES IN PAIN SENSITIVITY INDUCED BY RAISED ATMOSPHERIC-PRESSURE
    IGNATOV, YD
    MYASNIKOV, AA
    VASILEV, YN
    VINNICHUK, NN
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 1992, 114 (08) : 1123 - 1126
  • [28] Pressure Pain Sensitivity Mapping in Experimentally Induced Lateral Epicondylalgia
    Fernandez-Carnero, Josue
    Binderup, Asbjorn T.
    Ge, Hong-You
    Fernandez-De-Las-Penas, Cesar
    Arendt-Nielsen, Lars
    Madeleine, Pascal
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2010, 42 (05): : 922 - 927
  • [29] ACTION OF NEUROTROPIN ON COLD-INDUCED PAIN IN NORMAL VOLUNTEERS - A DOUBLE-BLIND PLACEBO STUDY
    THIEBAULD, C
    VANDEPUT, J
    LINTERMANS, J
    VANDENBOSCH, P
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1990, 4 (02) : 141 - 146
  • [30] TRPM8 and TRPA1 ideal targets for treating cold-induced pain
    Qi, Yiming
    Gong, Hao
    Shen, Zixian
    Wu, Limeng
    Xu, Zonghe
    Shi, Nuo
    Lin, Kexin
    Tian, Meng
    Xu, Zihua
    Li, Xiang
    Zhao, Qingchun
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 282