Using Human iPSCs for Psychiatric Disorder Disease Modeling and Mechanism-Based Drug Discovery

被引：1

作者：

Wen, Zhexing ^{[1
,2
]}

Guo, Ziyuan ^{[1
]}

Wang, Xinyuan ^{[1
]}

Kim, Namshik ^{[1
]}

Ross, Christopher ^{[1
]}

Margolis, Russell ^{[1
]}

Christian, Kimberly ^{[1
]}

Chen, Gong ^{[3
]}

Zheng, Wei ^{[4
]}

Xia, Menghang ^{[4
]}

Song, Hongjun ^{[1
]}

Ming, Guo-li ^{[1
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD 21218 USA

[2] Emory Univ, Atlanta, GA 30322 USA

[3] Penn State Univ, University Pk, PA 16802 USA

[4] Natl Ctr Advancing Translat Sci, Bethesda, MD USA

来源：

BIOLOGICAL PSYCHIATRY | 2017年 / 81卷 / 10期

关键词：

Schizophrenia; hIPSC; synapses; disease modeling;

D O I：

10.1016/j.biopsych.2017.02.784

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

717

引用

页码：S290 / S291

页数：2

共 50 条

[31] Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library
Testero, Sebastian A.
Granados, Carla
Fernandez, Daniel
Gallego, Pablo
Covaleda, Giovanni
Reverter, David
Vendrell, Josep
Aviles, Francesc X.
Pallares, Irantzu
Mobashery, Shahriar
[J]. ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (10): : 1122 - 1127
[32] Mechanism-based modeling of complex biomedical systems
Mosekilde, E
Sosnovtseva, OV
Holstein-Rathlou, NH
[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2005, 96 (03) : 212 - 224
[33] Computational Pharmaceutical Sciences and Mechanism-based Modeling
Borchardt, Ronald T.
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 107 (04) : 957 - 957
[34] Comprehensive Mechanism-Based Antibody Pharmacokinetic Modeling
Chabot, Jeffrey R.
Dettling, Danielle E.
Jasper, Paul J.
Gomes, Bruce C.
[J]. 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2011, : 4318 - 4323
[35] Mechanism-Based QSAR Modeling of Skin Sensitization
Dearden, J. C.
Hewitt, M.
Roberts, D. W.
Enoch, S. J.
Rowe, P. H.
Przybylak, K. R.
Vaughan-Williams, G. D.
Smith, M. L.
Pillai, G. G.
Katritzky, A. R.
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2015, 28 (10) : 1975 - 1986
[36] MECHANISM-BASED PKPD MODELING: PRINCIPLE AND APPLICATIONS
Danhof, M.
[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2011, 109 : 13 - 13
[37] ADME profiling in drug discovery: Comparison of rule-based computational alerts to mechanism-based simulation.
Bolger, MB
Fraczkiewicz, R
Steere, B
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U481 - U481
[38] Generating human bone marrow organoids for disease modeling and drug discovery
Olijnik, Aude-Anais
Rodriguez-Romera, Antonio
Wong, Zoe C.
Shen, Yuqi
Reyat, Jasmeet S.
Jooss, Natalie J.
Rayes, Julie
Psaila, Bethan
Khan, Abdullah O.
[J]. NATURE PROTOCOLS, 2024, 19 (07) : 2117 - 2146
[39] Human Engineered Heart Tissue Models for Disease Modeling and Drug Discovery
Tani, Hidenori
Tohyama, Shugo
[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
[40] Combined data-driven and mechanism-based approaches for human-intestinal-absorption prediction in the early drug-discovery stage
Handa, Koichi
Sugiyama, Sakae
Kageyama, Michiharu
Iijima, Takeshi
[J]. DIGITAL DISCOVERY, 2023, 2 (05): : 1577 - 1588

← 1 2 3 4 5 →