Synthesis of Diarylated 4-Pyridylmethyl Ethers via Palladium-Catalyzed Cross-Coupling Reactions

被引：9

作者：

Ablajan, Keyume ^{[1
]}

Panetti, Grace B. ^{[2
]}

Yang, Xiaodong ^{[3
]}

Kim, Byeong-Seon ^{[2
]}

Walsh, Patrick J. ^{[2
]}

机构：

[1] Xinjiang Univ, Coll Chem & Chem Engn, Minist Educ & Xinjiang Uyghur Autonomous Reg, Key Lab Oil & Gas Fine Chem, Urumqi 830046, Peoples R China

[2] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA

[3] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 11期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

aryl bromides; arylation; cross-coupling; diarylation; palladium catalyst; 4-pyridylmethyl ethers; C-H BONDS; C(SP(3))-H ARYLATION; DIARYLMETHANES; INHIBITORS;

D O I：

10.1002/adsc.201700380

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The direct arylation of weakly acidic sp(3)-hybridized C-H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a palladium(NIXANTPHOS)-based catalyst for the monoarylation of 4-pyridylmethyl 2-aryl ethers to generate diarylated 4-pyridyl methyl ethers is introduced. Furthermore, under similar conditions, the diarylation of 4-pyridyl methyl ethers with aryl bromides has been developed. These methods enable the synthesis of new pyridine derivatives, which are common in medicinally active compounds and have applications in materials science.

引用

页码：1927 / 1932

页数：6

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