Spiro Derivatives of 1,10b-dihydro-5H-pyrazolo[1,5-c][1,3]-benzoxazines and their Antimicrobial, Anti-Inflammatory, and Antioxidant Activity

被引：4
|
作者：
Mandzyuk, Lidiya Z. [1 ]
Matiychuk, Vasyl S. [2 ]
Chaban, Taras I. [3 ]
Bodnarchuk, Olesya V. [1 ]
Matiychuk, Julia E. [3 ]
Obushak, Mykola D. [2 ]
机构：
[1] Ivano Frankivsk Natl Med Univ, 2 Halytska St, UA-76018 Ivano Frankivsk, Ukraine
[2] Ivan Franko Natl Univ Lviv, 6 Kyryla & Mefodia St, UA-79005 Lvov, Ukraine
[3] Danylo Halytsky Lviv Natl Med Univ, 69 Pekarska St, UA-79010 Lvov, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
1,3-benzoxazines; chalcones; 1,3-oxazines; pyrazolines; pyrazolo[1,5-c][1,3]benzoxazines; anti-inflammatory activity; antimicrobial activity; antioxidant activity;
D O I：
10.1007/s10593-020-02842-x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols with cyclopentanone, cyclohexanone, or 4-methylcyclohexanone gave spiro derivatives of 1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazines. The antimicrobial, anti-inflammatory, and antioxidant activities of these compounds were studied. A compound with a high antimicrobial activity against S. aureus ATCC 43300, together with compounds possessing an anti-inflammatory effect superior to the reference drug diclofenac, as well as high antioxidant activity, were identified.
引用
收藏
页码：1485 / 1490
页数：6
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