Spiro Derivatives of 1,10b-dihydro-5H-pyrazolo[1,5-c][1,3]-benzoxazines and their Antimicrobial, Anti-Inflammatory, and Antioxidant Activity

被引：4

作者：

Mandzyuk, Lidiya Z. ^{[1
]}

Matiychuk, Vasyl S. ^{[2
]}

Chaban, Taras I. ^{[3
]}

Bodnarchuk, Olesya V. ^{[1
]}

Matiychuk, Julia E. ^{[3
]}

Obushak, Mykola D. ^{[2
]}

机构：

[1] Ivano Frankivsk Natl Med Univ, 2 Halytska St, UA-76018 Ivano Frankivsk, Ukraine

[2] Ivan Franko Natl Univ Lviv, 6 Kyryla & Mefodia St, UA-79005 Lvov, Ukraine

[3] Danylo Halytsky Lviv Natl Med Univ, 69 Pekarska St, UA-79010 Lvov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2020年 / 56卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

1,3-benzoxazines; chalcones; 1,3-oxazines; pyrazolines; pyrazolo[1,5-c][1,3]benzoxazines; anti-inflammatory activity; antimicrobial activity; antioxidant activity;

D O I：

10.1007/s10593-020-02842-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 2-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)phenols with cyclopentanone, cyclohexanone, or 4-methylcyclohexanone gave spiro derivatives of 1,10b-dihydropyrazolo[1,5-c][1,3]benzoxazines. The antimicrobial, anti-inflammatory, and antioxidant activities of these compounds were studied. A compound with a high antimicrobial activity against S. aureus ATCC 43300, together with compounds possessing an anti-inflammatory effect superior to the reference drug diclofenac, as well as high antioxidant activity, were identified.

引用

页码：1485 / 1490

页数：6

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