A genetically encodable cell-type-specific protein synthesis inhibitor

被引：14

作者：

Heumueller, Maximilian ^{[1
]}

Glock, Caspar ^{[1
]}

Rangaraju, Vidhya ^{[1
]}

Biever, Anne ^{[1
]}

Schuman, Erin M. ^{[1
]}

机构：

[1] Max Planck Inst Brain Res, Frankfurt, Germany

来源：

NATURE METHODS | 2019年 / 16卷 / 08期

基金：

欧洲研究理事会;

关键词：

RIBOSOME-INACTIVATING PROTEIN; VISUALIZATION;

D O I：

10.1038/s41592-019-0468-x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical inhibitors have revealed requirements for protein synthesis that drive cellular plasticity. We developed a genetically encodable protein synthesis inhibitor (gePSI) to achieve cell-type-specific temporal control of protein synthesis. Controlled expression of the gePSI in neurons or glia resulted in rapid, potent and reversible cell-autonomous inhibition of protein synthesis. Moreover, gePSI expression in a single neuron blocked the structural plasticity induced by single-synapse stimulation.

引用

页码：699 / +

页数：6

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