Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma

被引：11
|
作者：
Chen, Marcelo [1 ,2 ,3 ]
Yang, Ming-Hui [4 ,5 ]
Chang, Ming-Min [6 ]
Tyan, Yu-Chang [7 ,8 ,9 ,10 ,11 ,12 ]
Chen, Yi-Ming Arthur [5 ]
机构：
[1] Mackay Mem Hosp, Dept Urol, Taipei, Taiwan
[2] Mackay Jr Coll Med, Nursing & Managemen4 Taipei, Dept Cosmet Applicat & Management, Taipei, Taiwan
[3] Mackay Med Coll, Sch Med, New Taipei, Taiwan
[4] Natl Hlth Res Inst, Natl Mosquito Borne Dis Control Res Ctr, Miaoli, Taiwan
[5] Taipei Med Univ, Coll Pharm, Master Program Clin Pharmacogen & Pharmacoprote, 250 Wuxing St, Taipei 11031, Taiwan
[6] Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan, Taiwan
[7] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung, Taiwan
[8] Kaohsiung Med Univ, Dept Med Imaging & Radiol Sci, Kaohsiung, Taiwan
[9] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
[10] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung, Taiwan
[11] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan
[12] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 2019年 / 378卷
关键词：
Glycine N-methyltransferase; Detoxification; Hepatocellular carcinoma; Gene therapy; Drug screening; FOLATE-BINDING-PROTEIN; ARISTOLOCHIC ACID; UROTHELIAL CARCINOMA; SUSCEPTIBILITY GENE; TARGET ORGAN; /-MICE; EXPRESSION; DNA; NEPHROPATHY; DEFICIENCY;
D O I：
10.1016/j.taap.2019.114607
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo [a]pyrene, aflatoxin B1, and aristocholic acid. There is also increasing evidence suggesting a role of GNMT deficiency in liver carcinogenesis. In this review, we discuss the role of GNMT in the detoxification of xenobiotics and the mechanism of GNMT suppression during liver tumorigenesis. The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma. We describe the potential use of GNMT in gene therapy and we introduce the development of a GNMT promoter reporter assay that can be used to screen medicinal drugs and herbal libraries for natural compounds with anti-cancer properties.
引用
收藏
页数：7
相关论文
共 50 条
  • [41] GLYCINE N-METHYLTRANSFERASE IS A FOLATE BINDING-PROTEIN OF RAT-LIVER CYTOSOL
    COOK, RJ
    WAGNER, C
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (12): : 3631 - 3634
  • [42] Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver
    Liao, Yi-Jen
    Chen, Kuan-Hsuan
    Huang, Shiu-Feng
    Chen, Tzu-Lang
    Wang, Chung-Kwe
    Chien, Chau-Heng
    Tsai, Ting-Fen
    Liu, Shih-Ping
    Chen, Yi-Ming Arthur
    PROTEOMICS CLINICAL APPLICATIONS, 2010, 4 (04) : 394 - 406
  • [43] TISSUE DISTRIBUTION OF GLYCINE N-METHYLTRANSFERASE, A MAJOR FOLATE-BINDING PROTEIN OF LIVER
    YEO, EJ
    WAGNER, C
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) : 210 - 214
  • [44] Alterations of methionine metabolism in hepatocarcinogenesis: the emergent role of glycine N-methyltransferase in liver injury
    Simile, Maria M.
    Latte, Gavinella
    Feo, Claudio F.
    Feo, Francesco
    Calvisi, Diego F.
    Pascale, Rosa M.
    ANNALS OF GASTROENTEROLOGY, 2018, 31 (05): : 552 - 560
  • [45] Nicotinamide N-methyltransferase: a potential biomarker for worse prognosis in gastric carcinoma
    Chen, Chen
    Wang, Xin
    Huang, Xing
    Yong, Hongmei
    Shen, Jiajia
    Tang, Qi
    Zhu, Jin
    Ni, Jian
    Feng, Zhenqing
    AMERICAN JOURNAL OF CANCER RESEARCH, 2016, 6 (03): : 649 - 663
  • [46] Latexin exhibits tumor suppressor potential in hepatocellular carcinoma
    Ni, Qing-Feng
    Tian, Yuan
    Kong, Liang-Liang
    Lu, Ye-Ting
    Ding, Wen-Zhou
    Kong, Lian-Bao
    ONCOLOGY REPORTS, 2014, 31 (03) : 1364 - 1372
  • [47] The new research on tumor suppressor gene in hepatocellular carcinoma
    JI YubinYANG HaifanYU LeiPANG linlinLI HaijiaoLIU GuangdaCenter of Research and Development on Life Sciences and Environmental SciencesHarbin University of CommerceHarbin ChinaInstitute of Materia Medica and Postdoctoral Programme of Harbin University of CommerceHarbin ChinaEngineering Research Center of Natural Anticancer DrugsMinistry of EducationHarbin China
    沈阳药科大学学报, 2008, 25(S1) (S1) : 73 - 74
  • [48] Glycine N-Methyltransferase Is a Mediator of Cytochrome P4501A1 Gene Expression
    Arch Biochem Biophys, 2 (395):
  • [49] TOLL-LIKE RECEPTOR 3: A POTENTIAL TUMOR SUPPRESSOR GENE IN HEPATOCELLULAR CARCINOMA?
    Fares, N.
    Bonnin, M.
    Garcia, A.
    Testoni, B.
    Lefrancois, Lydie
    Bancel, B.
    Hervieu, V.
    Renno, T.
    Merle, P.
    Lebecque, S.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S572 - S572
  • [50] Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism
    Luka, Z
    Cerone, R
    Phillips, JA
    Mudd, SH
    Wagner, C
    HUMAN GENETICS, 2002, 110 (01) : 68 - 74
12345