Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma

被引：11
|
作者：
Chen, Marcelo [1 ,2 ,3 ]
Yang, Ming-Hui [4 ,5 ]
Chang, Ming-Min [6 ]
Tyan, Yu-Chang [7 ,8 ,9 ,10 ,11 ,12 ]
Chen, Yi-Ming Arthur [5 ]
机构：
[1] Mackay Mem Hosp, Dept Urol, Taipei, Taiwan
[2] Mackay Jr Coll Med, Nursing & Managemen4 Taipei, Dept Cosmet Applicat & Management, Taipei, Taiwan
[3] Mackay Med Coll, Sch Med, New Taipei, Taiwan
[4] Natl Hlth Res Inst, Natl Mosquito Borne Dis Control Res Ctr, Miaoli, Taiwan
[5] Taipei Med Univ, Coll Pharm, Master Program Clin Pharmacogen & Pharmacoprote, 250 Wuxing St, Taipei 11031, Taiwan
[6] Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan, Taiwan
[7] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung, Taiwan
[8] Kaohsiung Med Univ, Dept Med Imaging & Radiol Sci, Kaohsiung, Taiwan
[9] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
[10] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung, Taiwan
[11] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan
[12] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 2019年 / 378卷
关键词：
Glycine N-methyltransferase; Detoxification; Hepatocellular carcinoma; Gene therapy; Drug screening; FOLATE-BINDING-PROTEIN; ARISTOLOCHIC ACID; UROTHELIAL CARCINOMA; SUSCEPTIBILITY GENE; TARGET ORGAN; /-MICE; EXPRESSION; DNA; NEPHROPATHY; DEFICIENCY;
D O I：
10.1016/j.taap.2019.114607
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo [a]pyrene, aflatoxin B1, and aristocholic acid. There is also increasing evidence suggesting a role of GNMT deficiency in liver carcinogenesis. In this review, we discuss the role of GNMT in the detoxification of xenobiotics and the mechanism of GNMT suppression during liver tumorigenesis. The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma. We describe the potential use of GNMT in gene therapy and we introduce the development of a GNMT promoter reporter assay that can be used to screen medicinal drugs and herbal libraries for natural compounds with anti-cancer properties.
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页数：7
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