A Geometric Approach to Maximum Likelihood Estimation of the Functional Principal Components From Sparse Longitudinal Data

In this article, we consider the problem of estimating the eigenvalues and eigenfunctions of the covariance kernel (i.e., the functional principal components) from sparse and irregularly observed longitudinal data. We exploit the smoothness of the eigenfunctions to reduce dimensionality by restricting them to a lower dimensional space of smooth functions. We then approach this problem through a restricted maximum likelihood method. The estimation scheme is based oil a Newton-Raphson procedure oil the Stiefel manifold using the fact that the basis coefficient matrix for representing the eigenfunctions has orthonormal columns. We also address the selection of the number of basis functions, as well as that of the dimension of the covariance kernel by a second-order approximation to the leave-one-curve-out cross-validation score that is computationally very efficient. The effectiveness of our procedure is demonstrated by simulation studies and ail application to a CD4+ counts dataset. In the Simulation studies, our method performs well oil both estimation and model selection. It also Outperforms two existing approaches: one based on a local polynomial smoothing, and another using ail EM algorithm. Supplementary materials including technical details, the R package fpca, and data analyzed by this article are available online.