Cucurbitane-Type Triterpenoids from the African Plant Momordica balsamina

被引：40

作者：

Ramalhete, Catia ^{[1
]}

Mansoor, Tayyab A. ^{[1
]}

Mulhovo, Silva ^{[2
]}

Molnar, Joseph ^{[3
]}

Ferreira, Maria-Jose U. ^{[1
]}

机构：

[1] Univ Lisbon, iMed UL, Fac Farm, P-1600083 Lisbon, Portugal

[2] ISPG, Chokwe, Mozambique

[3] Univ Szeged, Dept Med Microbiol & Immunol, H-6720 Szeged, Hungary

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 11期

关键词：

ANTIPLASMODIAL ACTIVITY; CANCER-CELLS; IN-VITRO; LEAVES; CYCLOARTANES; TERPENOIDS; DITERPENES; GLYCOSIDES; EXTRACTS;

D O I：

10.1021/np900457u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of the aerial parts of Momordica balsamina led to the isolation of five new cucurbitane-type triterpenoids (1-5) and two known analogues (6, 7). Their structures were elucidated on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC, and NOESY). The new compounds feature unusual oxidation patterns in the cucurbitane skeleton, such as at C-29 (1-3) and C-12 (4, 5). Compounds 1-4, 6, and 7 were evaluated for in vitro cytotoxicity against human breast cancer cells (MCF-7), using the MTT assay.

引用

页码：2009 / 2013

页数：5

共 50 条

[41] One new 19-nor cucurbitane-type triterpenoid from the stems of Momordica charantia
Li, Yong-chao
Xu, Xin-juan
Yang, Jing
Wu, Xing-gang
Fu, Qing-yun
NATURAL PRODUCT RESEARCH, 2016, 30 (08) : 973 - 978
[42] New Cucurbitane Triterpenoids and Steroidal Glycoside from Momordica charantia
Liu, Jie-Qing
Chen, Jian-Chao
Wang, Cui-Fang
Qiu, Ming-Hua
MOLECULES, 2009, 14 (12) : 4804 - 4813
[43] Two new cucurbitane triterpenoids from the seeds of Momordica charantia
Ma, Lin
Yu, Ai-Hua
Sun, Li-Li
Gao, Wan
Zhang, Meng-Meng
Su, Ya-Lun
Liu, Hua
Ji, Teng-Fei
Li, Di-Zao
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2014, 16 (05) : 476 - 482
[44] Two new cucurbitane triterpenoids from Momordica charantia L.
Jia Qing Cao~a
Chinese Chemical Letters, 2011, 22 (05) : 583 - 586
[45] Two New Cucurbitane Triterpenoids from Immature Fruits of Momordica charantia
Li, Zhen-Jie
Chen, Jian-Chao
Deng, Yuan-Yuan
Song, Na-Li
Yu, Mu-Yuan
Zhou, Lin
Qiu, Ming-Hua
HELVETICA CHIMICA ACTA, 2015, 98 (10) : 1456 - 1461
[46] Cucurbitane Triterpenoids from the Fruit Pulp of Momordica charantia and Their Cytotoxic Activity
Liao, Yun-Wen
Chen, Chiy-Rong
Chuu, Jiunn-Jye
Huang, Hui-Chi
Hsu, Jue-Liang
Huang, Tzou-Chi
Kuo, Yueh-Hsiung
Chang, Chi-I
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2013, 60 (05) : 526 - 530
[47] Kuguacins F-S, cucurbitane triterpenoids from Momordica charantia
Chen, Jian-Chao
Liu, Wu-Qing
Lu, Lu
Qju, Ming-Hua
Zheng, Yong-Tang
Yang, Liu-Meng
Zhang, Xian-Min
Zhou, Lin
Li, Zhong-Rong
PHYTOCHEMISTRY, 2009, 70 (01) : 133 - 140
[48] Two new cucurbitane triterpenoids from Momordica charantia L.
Cao, Jia Qing
Zhang, Yu
Cui, Jiong Mo
Zhao, Yu Qing
CHINESE CHEMICAL LETTERS, 2011, 22 (05) : 583 - 586
[49] THE EFFICACY OF CUCURBITANE TYPE TRITERPENOIDS, GLYCOSIDES AND PHENOLIC COMPOUNDS ISOLATED FROM MOMORDICA CHARANTIA: A REVIEW
Haque, M. Ekramul
Alam, M. Badrul
Hossain, M. Sarowar
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (05): : 1135 - 1146
[50] Cucurbitane-type triterpenes and glycoside from the rattan of wild Momordica charantia and their anti-inflammatory and cytotoxic activities
Zhang, L. J.
Huang, H. T.
Liaw, C. C.
Huang, S. Y.
Lin, Z. H.
Kuo, Y. H.
PLANTA MEDICA, 2016, 82

← 1 2 3 4 5 →