Cucurbitane-Type Triterpenoids from the African Plant Momordica balsamina

被引：40

作者：

Ramalhete, Catia ^{[1
]}

Mansoor, Tayyab A. ^{[1
]}

Mulhovo, Silva ^{[2
]}

Molnar, Joseph ^{[3
]}

Ferreira, Maria-Jose U. ^{[1
]}

机构：

[1] Univ Lisbon, iMed UL, Fac Farm, P-1600083 Lisbon, Portugal

[2] ISPG, Chokwe, Mozambique

[3] Univ Szeged, Dept Med Microbiol & Immunol, H-6720 Szeged, Hungary

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 11期

关键词：

ANTIPLASMODIAL ACTIVITY; CANCER-CELLS; IN-VITRO; LEAVES; CYCLOARTANES; TERPENOIDS; DITERPENES; GLYCOSIDES; EXTRACTS;

D O I：

10.1021/np900457u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation of the aerial parts of Momordica balsamina led to the isolation of five new cucurbitane-type triterpenoids (1-5) and two known analogues (6, 7). Their structures were elucidated on the basis of spectroscopic methods including 2D NMR experiments (COSY, HMQC, HMBC, and NOESY). The new compounds feature unusual oxidation patterns in the cucurbitane skeleton, such as at C-29 (1-3) and C-12 (4, 5). Compounds 1-4, 6, and 7 were evaluated for in vitro cytotoxicity against human breast cancer cells (MCF-7), using the MTT assay.

引用

页码：2009 / 2013

页数：5

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