Palladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-lodoazetidine: Synthesis of 3-Arylazetidines

被引：13

作者：

Liu, Zhenwei ^{[1
]}

Luan, Nannan ^{[1
]}

Shen, Linhua ^{[1
]}

Li, Jingya ^{[2
,3
]}

Zou, Dapeng ^{[1
]}

Wu, Yusheng ^{[1
,2
,3
,4
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Henan, Peoples R China

[2] Tetranov Biopharm LLC, Zhengzhou 450052, Henan, Peoples R China

[3] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450052, Henan, Peoples R China

[4] Tetranov Int Inc, 100 Jersey Ave,Suite A340, New Brunswick, NJ 08901 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 19期

基金：

中国国家自然科学基金;

关键词：

NICOTINE ANALOGS; ALKYL-HALIDES; ARYL; AZETIDINES; ACCESS; BROMIDES; DERIVATIVES; SILYLATION; ARYLATION; NICKEL;

D O I：

10.1021/acs.joc.9b01715

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical laboratories in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions.

引用

页码：12358 / 12365

页数：8

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