Palladium-catalyzed Hiyama cross-couplings of pyrimidin-2-yl tosylates with organosilanes

被引：0
|
作者：
Gong, Hai-Peng [1 ]
Quan, Zheng-Jun [2 ]
Wang, Xi-Cun [2 ]
机构：
[1] Gansu Agr Univ, Coll Sci, Lanzhou 730070, Gansu, Peoples R China
[2] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2022年 / 46卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Hiyama reaction; pyrimidin-2-yl tosylates; organosilanes; TBAF; arylation; ROOM-TEMPERATURE; ARYL BROMIDES; TRIALLYL(ARYL)SILANES; CHLORIDES; REAGENTS; HALIDES;
D O I：
10.1177/17475198211067163
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient palladium-catalyzed Hiyama reaction between various pyrimidin-2-yl tosylates with organosilanes has been developed. The use of CuCl with TBAF as additive is essential for promotion of the construction of the carbon-carbon bond. This procedure shows wide functional group tolerance for electrophilic pyrimidin-2-yl tosylates and has been extended to aromatic amino-substituted pyrimidin-2-yl tosylates, affording the desired C2-aryl and alkenyl pyrimidine derivatives in good to excellent yields.
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页数：7
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