Automated radiosynthesis of [11C]L-deprenyl-D2 and [11C]D-deprenyl using a commercial platform

Two C-11-labelled PET tracers, (R)-N-[C-11]methyl-N-(3,3-dideuteropropargyl)-1-phenylpropan-2-amine ([C-11]L-deprenyl-D-2, [C-11]DED) and (S)-N-[C-11]methyl-N-propargyl-1-phenylpropan-2-amine ([C-11]D-deprenyl, [C-11]DDE) were synthesised. One step N-alkylation with [C-11]MeI or [C-11]MeOTf was performed using the automated platform TRACERlab (R) FX-C Pro. The labelled products were obtained with (37 +/- 15)% (n=10) (end of synthesis, decay corrected from [C-11]MeI) radiochemical yields from [C-11]MeI after 38 +/- 3 min synthesis time. In all cases, radiochemical purity was over 99% when [C-11]MeOTf was used. This synthesis using a commercial platform makes these tracers more accessible for clinical research purposes. (C) 2015 Elsevier Ltd. All rights reserved.