Automated radiosynthesis of [11C]morphine for clinical investigation

被引：2

作者：

Fan, Jinda ^{[1
]}

Meissner, Konrad ^{[2
]}

Gaehle, Gregory G. ^{[1
]}

Li, Shihong ^{[1
]}

Kharasch, Evan D. ^{[2
]}

Mach, Robert H. ^{[1
]}

Tu, Zhude ^{[1
]}

机构：

[1] Washington Univ, Dept Radiol, Sch Med, St Louis, MO 63110 USA

[2] Washington Univ, Dept Anesthesiol, Sch Med, St Louis, MO 63110 USA

来源：

APPLIED RADIATION AND ISOTOPES | 2011年 / 69卷 / 02期

基金：

美国国家卫生研究院;

关键词：

C-11]morphine; Automated radiosynthesis; Positron emission tomography; BLOOD-BRAIN-BARRIER; P-GLYCOPROTEIN TRANSPORT; ENDOTHELIAL-CELLS; MORPHINE; GENE; FENTANYL; RAT;

D O I：

10.1016/j.apradiso.2010.11.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

To meet a multiple-dose clinical evaluation of the P-gp modulation of [C-11]morphine delivery into the human brain, radiosynthesis of [(11)(C)]morphine was accomplished on an automated system by N-methylation of normorphine with [C-11]CH3I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45 min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26 Ci/mu mol (decay corrected to end-of-bombardment): radiochemical and chemical purities were >95% (n=28). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：431 / 435

页数：5

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